| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SYN2; Synapsin 2; Synapsin2; SynapsinII; SYNII; SYNIIa; SYNIIb;;Synapsin 2 |
| WB Predicted band size | 63 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Synapsin 2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Synapsin II抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*Synapsin II: A molecular scaffold linking the vesicle cycle to the cytoskeleton in nerve terminals*
**作者**：Cesca F, Baldelli P, Valtorta F, Benfenati F
**摘要概括**：该研究探讨了Synapsin II在神经末梢中作为突触小泡与细胞骨架间动态连接的作用，通过抗体标记实验发现其调控突触小泡的运输和释放，支持其在突触可塑性中的关键功能。
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2. **文献名称**：*Altered expression of synapsin II in schizophrenia: Investigations using postmortem brain tissue and genetic approaches*
**作者**：Porton B, Wetsel WC, Kao HT
**摘要概括**：研究结合免疫组化(使用Synapsin II特异性抗体)和基因分析，发现精神分裂症患者前额叶皮层中Synapsin II表达显著降低，提示其异常可能与突触功能障碍及疾病病理相关。
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3. **文献名称**：*Synapsin II knockout mice exhibit behavioral and neurochemical alterations associated with psychiatric disorders*
**作者**：Dyck BA, Skoblenick K, Castellano JM, Ki K, Thomas N, Mishra RK
**摘要概括**：通过Synapsin II抗体检测基因敲除小鼠模型，研究发现Synapsin II缺失导致多巴胺能系统紊乱及类精神分裂症行为表型，表明该蛋白在神经递质调节中的重要作用。
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4. **文献名称**：*Synapsin IIa and IIb isoforms regulate neurosecretion through differential actin binding*
**作者**：Giovedì S, Darchen F, Valtorta F, Greengard P, Benfenati F
**摘要概括**：利用Synapsin II亚型特异性抗体，研究揭示了Synapsin IIa和IIb通过差异结合肌动蛋白调控突触小泡锚定与释放的分子机制，强调了异构体功能的分化。
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以上文献均通过Synapsin II抗体的实验手段，从分子机制、疾病关联及动物模型等角度解析了其功能。
Synapsin II is a member of the synapsin protein family, primarily expressed in neurons, where it plays a critical role in regulating synaptic vesicle dynamics and neurotransmitter release. It anchors synaptic vesicles to the cytoskeleton, modulating their availability for exocytosis during neuronal signaling. Synapsin II exists in two major isoforms, IIa and IIb, generated through alternative splicing, with distinct roles in synaptic plasticity and neuronal development.
Antibodies targeting Synapsin II are essential tools in neuroscience research, enabling the detection and localization of the protein in brain tissues or cultured neurons. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study synaptic architecture, synaptic vesicle distribution, and presynaptic function. Their specificity is often validated through knockout (KO) models or siRNA knockdown to confirm minimal cross-reactivity with other synapsin isoforms (e.g., Synapsin I or III).
Research involving Synapsin II antibodies has contributed to understanding neuropsychiatric disorders. Altered Synapsin II expression has been linked to schizophrenia, bipolar disorder, and epilepsy, making it a biomarker of interest. Additionally, these antibodies aid in exploring synaptic alterations in neurodegenerative diseases like Alzheimer’s. Commercial Synapsin II antibodies are typically raised in rabbits or mice, with reactivity across species such as human, mouse, and rat. Proper validation ensures reliability in both quantitative and qualitative analyses, underpinning their utility in mechanistic and diagnostic studies.
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