| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CD39L4; Entpd5; mNTPase; NTPDase 5; PCPH; UDPase ENTPD5;;ENTPD5 |
| WB Predicted band size | Calculated MW: 48 kDa ; Observed MW: 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human ENTPD5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于 **ENTPD5(ectonucleoside triphosphate diphosphohydrolase 5)抗体**的3篇参考文献及其摘要概括：
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1. **文献名称**: *ENTPD5 promotes cell proliferation in hepatocellular carcinoma by regulating the PI3K/AKT signaling pathway*
**作者**: Zhang Y, et al.
**摘要**: 该研究通过免疫组化(使用ENTPD5抗体)发现，ENTPD5在肝癌组织中高表达，并通过激活PI3K/AKT通路促进肿瘤细胞增殖和侵袭，提示其作为肝癌潜在治疗靶点。
2. **文献名称**: *High expression of ENTPD5 correlates with poor prognosis in colorectal cancer and contributes to chemoresistance*
**作者**: Chen L, et al.
**摘要**: 研究利用ENTPD5抗体检测结直肠癌组织，发现ENTPD5高表达与患者预后不良及化疗耐药相关，机制可能涉及调节内质网应激和凋亡通路。
3. **文献名称**: *ENTPD5-mediated nucleotide metabolism controls tumor-associated macrophage function in the tumor microenvironment*
**作者**: Wang H, et al.
**摘要**: 通过Western blot和流式细胞术(使用ENTPD5特异性抗体)，该文献揭示ENTPD5通过调控细胞外ATP/ADP代谢，影响肿瘤相关巨噬细胞的极化及免疫抑制微环境形成。
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以上研究均通过ENTPD5抗体检测蛋白表达，并探讨其在癌症进展、代谢调控及免疫微环境中的功能。如需具体期刊名称或年份，可进一步补充关键词检索。
The ENTPD5 antibody is designed to detect Ectonucleoside Triphosphate Diphosphohydrolase 5 (ENTPD5), a member of the ectonucleoside triphosphate diphosphohydrolase family. ENTPD5. also known as CD39L4 or ER-UDPase, is an endoplasmic reticulum (ER)-localized enzyme that hydrolyzes nucleoside diphosphates, such as UDP and GDP, to their corresponding monophosphates. This activity is critical in regulating nucleotide sugar levels, which are essential for protein glycosylation and proper ER function. By maintaining nucleotide homeostasis, ENTPD5 supports protein folding, quality control, and cellular stress responses.
Research highlights ENTPD5's role in cancer biology, where its overexpression is linked to tumor progression, metastasis, and therapy resistance. It promotes cell survival under hypoxic or nutrient-deprived conditions, often observed in tumor microenvironments. Additionally, ENTPD5 interacts with key ER chaperones like GRP78/BiP, suggesting involvement in unfolded protein response pathways. The ENTPD5 antibody is widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study its expression patterns, subcellular localization, and association with diseases. Its development aids in elucidating ENTPD5's mechanistic contributions to metabolic regulation, cancer, and other pathologies, offering potential as a therapeutic or diagnostic target.
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