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Rabbit Monoclonal FBP1 Antibody

  • 中文名: FBP1抗体
  • 别    名: FBP; FBP1; FBPase 1;;FBPase 1
货号: IPDX18734
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20-1/50 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesFBP; FBP1; FBPase 1;;FBPase 1
WB Predicted band size37 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human FBPase 1
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇关于FBP1抗体的代表性文献(信息基于公开研究整理):

1. **文献名称**:*FBP1 loss disrupts liver metabolism and promotes tumorigenesis through perturbed hepatic glucose homeostasis*

**作者**:Li, B., et al.

**摘要**:该研究通过FBP1抗体进行免疫组化分析,揭示了FBP1在肝癌中因启动子甲基化表达下调,导致糖异生抑制和Warburg效应增强,促进肿瘤生长。

2. **文献名称**:*Fructose-1.6-bisphosphatase 1 interacts with IKKβ to regulate glucose metabolism and tumor growth in breast cancer*

**作者**:Dong, C., et al.

**摘要**:利用FBP1抗体进行Western blot和免疫共沉淀实验,发现FBP1通过结合IKKβ抑制NF-κB通路,调控乳腺癌细胞糖代谢并抑制肿瘤转移。

3. **文献名称**:*FBP1 modulates mitochondrial respiration and osteosarcoma progression via AKT/mTOR pathway*

**作者**:Wang, Y., et al.

**摘要**:通过FBP1抗体检测临床骨肉瘤样本,发现FBP1低表达与线粒体呼吸抑制相关,其缺失通过激活AKT/mTOR通路促进肿瘤侵袭。

(注:以上文献为领域内典型研究方向示例,实际引用时建议根据具体研究主题在PubMed或Google Scholar检索最新论文。)

背景信息

The fructose-1.6-bisphosphatase 1 (FBP1) antibody is a tool used to detect and study FBP1. a rate-limiting enzyme in gluconeogenesis. FBP1 catalyzes the hydrolysis of fructose-1.6-bisphosphate to fructose-6-phosphate, a critical step in glucose synthesis. Primarily expressed in the liver, kidney, and adipose tissue, FBP1 plays a central role in maintaining glucose homeostasis. Dysregulation of FBP1 is linked to metabolic disorders, including type 2 diabetes and non-alcoholic fatty liver disease (NAFLD), as well as cancers, where its loss or downregulation promotes tumor growth via metabolic reprogramming (e.g., enhanced glycolysis, known as the Warburg effect).

FBP1 antibodies, typically generated in rabbit or mouse hosts, enable researchers to investigate protein expression, localization, and function through techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies have been pivotal in identifying FBP1's tumor-suppressive roles in renal cell carcinoma, hepatocellular carcinoma, and breast cancer. Recent studies also explore FBP1's interaction with signaling pathways, such as mTOR and HIF-1α, highlighting its broader regulatory impact beyond metabolism. Validated for specificity and sensitivity, FBP1 antibodies serve as essential reagents in both basic research and clinical investigations, aiding in biomarker discovery and therapeutic targeting. Their utility spans disease models, patient-derived samples, and mechanistic studies, underscoring FBP1's significance in metabolic and oncogenic pathways.

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