| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ALDH1A2; Aldh1a7; AV116159; RALDH 2; RALDH(II); Raldh1; RalDH2; RALDH2 T;;ALDH1A2 |
| WB Predicted band size | 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human ALDH1A2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于ALDH1A2抗体的3篇参考文献的简要信息：
1. **文献名称**：Aldh1a2 is a marker of mesoderm-derived neural crest cells during development
**作者**：Niederreither et al.
**摘要**：研究证实ALDH1A2在胚胎发育中作为视黄酸合成的关键酶，其抗体被用于标记神经嵴细胞谱系，揭示了其在体节形成和器官发生中的作用。
2. **文献名称**：ALDH1A2 expression correlates with tumor-initiating potential in colorectal cancer
**作者**：Chen et al.
**摘要**：通过ALDH1A2抗体检测，发现其在结直肠癌干细胞中高表达，提示其作为癌症干细胞标志物的潜力，并与化疗耐药性相关。
3. **文献名称**：Retinoic acid synthesis by ALDH1A2 is essential for kidney development
**作者**：Rhinn et al.
**摘要**：利用ALDH1A2抗体进行组织定位，发现该酶在胚胎肾脏发育中调控视黄酸信号通路，基因敲除导致肾脏形态异常。
注：以上为模拟示例，实际文献需通过PubMed等数据库检索确认。若需具体文献，建议使用关键词"ALDH1A2 antibody"结合研究领域(如癌症、发育生物学)进行精准检索。
ALDH1A2. a member of the aldehyde dehydrogenase 1A family, is a key enzyme in retinoic acid (RA) biosynthesis, catalyzing the oxidation of retinaldehyde to RA. This enzyme plays critical roles in embryonic development, cellular differentiation, and tissue homeostasis. Dysregulation of ALDH1A2 has been implicated in developmental disorders, metabolic diseases, and cancers, making it a subject of interest in both basic and clinical research.
Antibodies targeting ALDH1A2 are essential tools for detecting and quantifying its expression in various biological samples. They are widely used in techniques such as immunohistochemistry (IHC), Western blotting, and immunofluorescence to study tissue-specific expression patterns, subcellular localization, and regulatory mechanisms. In cancer research, ALDH1A2 antibodies help investigate its dual role as a tumor suppressor (by modulating RA signaling) or promoter (in certain contexts like stemness maintenance).
Commercially available ALDH1A2 antibodies are typically validated for specificity and sensitivity across species, including human, mouse, and rat. Researchers often verify antibody performance using knockout controls or siRNA-mediated knockdown. Despite their utility, variability in antibody performance across experimental conditions underscores the need for careful optimization. Overall, ALDH1A2 antibodies remain vital for elucidating its biological functions and therapeutic potential in diseases linked to RA signaling pathways.
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