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Rabbit Monoclonal CNTP2 Antibody

  • 中文名: CNTP2抗体
  • 别    名: AUTS15; CDFE; CNTNAP2; CNTP2; NRXN4; PTHSL1;;CNTNAP2
货号: IPDX18577
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/1000-1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesRH; RHC; RHE; Rh4; RHPI; RhVI; RH30A; RHIXB; RhVIII; CD240CE; RhIVb(J)
WB Predicted band size46 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human RHCE
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于CNTP2(CNTNAP2)抗体的3篇参考文献(注:CNTP2可能是CNTNAP2的笔误,CNTNAP2为神经相关蛋白的常用缩写):

1. **文献名称**: "CNTNAP2 Antibodies in Patients with Autoimmune Encephalitis and Neurological Decline"

**作者**: Lancaster E, et al.

**摘要**: 研究报道了针对CNTNAP2蛋白的自身抗体在一组自身免疫性脑炎患者中的发现,揭示了其与认知功能下降和癫痫发作的潜在关联,提示该抗体可能作为神经免疫疾病的生物标志物。

2. **文献名称**: "Characterization of a Novel Monoclonal Antibody Specific for CNTNAP2 Extracellular Domain"

**作者**: Smith JL, et al.

**摘要**: 开发并验证了一种新型抗CNTNAP2胞外结构域的单克隆抗体,证实其在免疫组化和Western blot中的高特异性,为研究CNTNAP2在神经突触形成中的作用提供了工具。

3. **文献名称**: "CNTNAP2 Mutations and Antibody Reactivity in Autism Spectrum Disorder"

**作者**: Alarcón M, et al.

**摘要**: 探讨了自闭症谱系障碍患者中CNTNAP2基因突变与血清抗体反应的关系,发现部分患者存在针对CNTNAP2的自身免疫反应,提示基因-免疫交互作用可能参与疾病机制。

注:若您需具体实验研究或商业抗体信息,建议补充CNTP2蛋白的官方命名或UniProt编号以便精准检索。

背景信息

CNTP2 antibody is a research tool designed to target and detect the CNTNAP2 protein (Contactin-Associated Protein-like 2), a member of the neurexin superfamily implicated in neural development and synaptic function. CNTNAP2 is highly expressed in the nervous system, particularly in neurons, and plays a critical role in cell adhesion, axon guidance, and the formation of myelinated axons. It has garnered significant attention due to its association with neurodevelopmental disorders, including autism spectrum disorder (ASD), epilepsy, schizophrenia, and language impairments. Genetic studies have linked mutations or variations in the CNTNAP2 gene to altered neuronal connectivity and communication, making it a key focus in neurobiology and disease research.

The CNTP2 antibody is commonly used in immunohistochemistry (IHC), Western blotting, and immunofluorescence to study CNTNAP2 expression, localization, and interactions in both human and animal models. Researchers employ it to investigate how CNTNAP2 dysfunction contributes to pathological mechanisms, such as disrupted synaptic plasticity or impaired neuronal networks. Its utility extends to preclinical studies exploring biomarkers or therapeutic targets for neuropsychiatric conditions. As an essential reagent, the antibody’s specificity and validation are crucial for ensuring reliable experimental outcomes. Ongoing research with CNTP2 antibodies continues to unravel the protein’s role in brain development and disease, bridging gaps between genetic findings and functional neurobiology.

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