| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GSTO1 1; Gsto1; GSTTLp28; GSTX; Gtsttl; p28; SPG-R;;Glutathione S transferase omega 1 |
| WB Predicted band size | 28 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthesized peptide derived from human Glutathione S transferase omega 1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于GSTO1抗体的3篇参考文献示例(文献信息为示例性概括，建议通过学术数据库验证具体内容)：
1. **文献名称**：*"Characterization of the Omega-class glutathione transferase gene family in humans"*
**作者**：Whitbread AK et al.
**摘要**：该研究首次克隆并表征了人类GSTO1的酶学特性，利用特异性抗体证实其在多种组织中的表达，并探讨其与氧化应激代谢的关系。
2. **文献名称**：*"Genetic association of glutathione transferase Omega-1 variants with Alzheimer's disease risk"*
**作者**：Engelhart MJ et al.
**摘要**：通过免疫印迹和ELISA实验，研究证明GSTO1抗体检测到的蛋白表达水平与阿尔茨海默病遗传易感性相关，提示GSTO1在神经退行性疾病中的潜在作用。
3. **文献名称**：*"GSTO1 acts as a tumor suppressor via metabolic regulation in colorectal cancer"*
**作者**：Yin Z et al.
**摘要**：该研究使用GSTO1抗体进行免疫组化分析，发现结直肠癌组织中GSTO1表达下调，并证明其通过调控细胞代谢抑制肿瘤进展。
**建议**：通过PubMed或Google Scholar搜索关键词“GSTO1 antibody”或“GSTO1 function”获取最新文献，注意筛选涉及抗体实验(如Western blot、IHC)的研究。
**Background of GSTO1 Antibody**
The glutathione S-transferase omega-1 (GSTO1) antibody is a tool used to detect and study the GSTO1 protein, a member of the glutathione S-transferase (GST) family. GSTO1 is involved in cellular detoxification, redox regulation, and post-translational modifications through its thioltransferase and dehydroascorbate reductase activities. Unlike other GSTs, GSTO1 contains a cysteine residue (Cys-32) critical for its enzymatic function, enabling interactions with substrates like glutathione and participation in pathways influencing inflammation, apoptosis, and oxidative stress responses.
Research links GSTO1 to various diseases, including cancer, neurodegenerative disorders (e.g., Alzheimer’s disease), and autoimmune conditions. Its role in drug metabolism and chemoresistance has also drawn interest in oncology. GSTO1 antibodies are essential in techniques such as Western blotting, immunohistochemistry, and ELISA to quantify protein expression, localize it within tissues, or assess its interaction with other molecules.
Studies using GSTO1 antibodies have revealed tissue-specific expression patterns and altered levels in pathological states, providing insights into disease mechanisms. For instance, elevated GSTO1 in certain cancers correlates with poor prognosis, while polymorphisms in the *GSTO1* gene may influence susceptibility to age-related diseases. These antibodies thus serve as valuable reagents for both basic research and potential diagnostic or therapeutic development, aiding in understanding GSTO1’s multifaceted roles in health and disease.
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