| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AI1H |
| WB Predicted band size | 86 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ITGB6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IMPDH2抗体的3篇参考文献示例(内容基于模拟生成，仅供参考)：
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1. **文献名称**：*IMPDH2 overexpression correlates with poor prognosis and immune infiltration in hepatocellular carcinoma*
**作者**：Li, X. et al.
**摘要**：该研究通过免疫组化(IHC)和Western blot分析IMPDH2在肝癌组织中的表达，发现其高表达与患者预后不良相关，并可能通过调节肿瘤微环境中的免疫细胞浸润促进肝癌进展。
2. **文献名称**：*IMPDH2 regulates mitochondrial function and antiviral responses in influenza A virus infection*
**作者**：Wang, Y. et al.
**摘要**：本文利用IMPDH2抗体进行免疫荧光和蛋白质印迹实验，证明甲型流感病毒通过上调IMPDH2表达促进病毒复制，并揭示其通过调控线粒体代谢增强宿主抗病毒反应的机制。
3. **文献名称**：*Targeting IMPDH2 induces differentiation in acute myeloid leukemia cells*
**作者**：Chen, J. et al.
**摘要**：研究使用IMPDH2抗体检测白血病细胞中蛋白水平变化，发现抑制IMPDH2可诱导AML细胞分化并抑制增殖，提示其作为白血病治疗靶点的潜力。
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如需具体文献，建议通过PubMed或Google Scholar搜索关键词“IMPDH2 antibody”、“IMPDH2 immunohistochemistry”等获取最新研究。
IMPDH2 (Inosine-5'-monophosphate dehydrogenase 2) is a key enzyme in the de novo biosynthesis of guanine nucleotides, catalyzing the rate-limiting step of converting inosine monophosphate (IMP) to xanthosine monophosphate (XMP). This metabolic pathway is critical for cellular proliferation, immune function, and nucleic acid synthesis. IMPDH2. the predominant isoform in most proliferating cells, is upregulated in rapidly dividing tissues and malignancies, making it a potential biomarker for cancer progression and a therapeutic target.
Antibodies targeting IMPDH2 are essential tools for studying its expression, localization, and regulatory roles in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess IMPDH2 levels in cancer models, immune disorders, and viral infections (e.g., hepatitis C), where nucleotide metabolism is dysregulated. Research has linked IMPDH2 overexpression to poor prognosis in cancers, including leukemia and solid tumors, and its inhibition (e.g., by mycophenolic acid) suppresses lymphocyte proliferation, highlighting relevance in autoimmune disease therapy.
IMPDH2 antibodies also aid in exploring its non-catalytic roles, such as interactions with cytoskeletal proteins or participation in cellular stress responses. Validated antibodies with high specificity are crucial to distinguish IMPDH2 from its isoform IMPDH1 and avoid cross-reactivity. These reagents continue to advance studies in drug development, metabolic diseases, and mechanisms of chemotherapeutic resistance.
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