| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AR7; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; NR1A1; THRA; THRA1; THRA2;;Thyroid hormone receptor alpha |
| WB Predicted band size | 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Thyroid hormone receptor alpha |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于THRA抗体的3篇参考文献，包括文献名称、作者及摘要内容概括：
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1. **文献名称**: *"Mutations in the thyroid hormone receptor alpha gene (THRA) as a cause of thyroid hormone resistance"*
**作者**: Refetoff S, et al.
**摘要**: 该研究首次报道了THRA基因突变导致甲状腺激素抵抗综合征的机制，通过特异性抗体检测突变受体在细胞内的异常表达，揭示了突变体对甲状腺激素信号通路的干扰作用。
2. **文献名称**: *"The role of thyroid hormone receptor alpha in cancer progression"*
**作者**: Brent GA, et al.
**摘要**: 综述了THRA在肿瘤发生中的作用，重点讨论了利用THRA抗体检测其表达水平与癌症分型的相关性，并探索其在乳腺癌和白血病中的潜在治疗靶点价值。
3. **文献名称**: *"Development of a monoclonal antibody targeting thyroid hormone receptor alpha for therapeutic intervention in acute myeloid leukemia"*
**作者**: Smith J, et al.
**摘要**: 研究团队开发了一种高特异性THRA单克隆抗体，体外实验显示其可通过阻断受体二聚化抑制白血病细胞增殖，为THRA靶向治疗提供了实验依据。
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注：以上文献信息为示例，实际研究中建议通过PubMed或Web of Science检索最新文献。若需具体文献，可补充提供DOI或PMID进一步查询。
Thyroid hormone receptor alpha (THRA) antibodies are tools used to study the THRA protein, a member of the nuclear receptor superfamily that mediates thyroid hormone signaling. THRA, encoded by the THRA gene, regulates gene expression by binding to thyroid hormones (T3/T4) and interacting with DNA response elements. It plays critical roles in metabolism, development, and cardiovascular function. Dysregulation of THRA is linked to thyroid hormone resistance syndromes, cancers, and metabolic disorders.
THRA antibodies are essential in detecting and analyzing the receptor’s expression, localization, and post-translational modifications in research. They are used in techniques like Western blot, immunohistochemistry, and chromatin immunoprecipitation to explore THRA’s role in cellular processes and disease mechanisms. For instance, mutations in THRA can cause impaired hormone binding or cofactor interactions, leading to developmental defects or tissue-specific hormone resistance.
A key challenge in developing THRA antibodies lies in ensuring specificity, as THRA shares structural homology with other nuclear receptors, particularly thyroid hormone receptor beta (THRB). High-quality antibodies are validated using knockout controls or epitope-mapping to avoid cross-reactivity. Additionally, alternative splicing generates THRA isoforms (e.g., TRα1 and TRα2), requiring antibodies that distinguish between variants. These reagents advance understanding of THRA’s dual roles as a transcriptional activator and repressor, offering insights into therapeutic targets for thyroid-related pathologies.
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