| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ETV6; Tel; TEL oncogene; TEL/ABL; TEL1;;ETV6 |
| WB Predicted band size | 53 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human ETV6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于ETTV6抗体的3篇参考文献示例(注：以下为虚拟文献，实际引用时请核实真实来源)：
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1. **标题**：*"A Monoclonal Antibody Against ETV6 for the Detection of Chromosomal Translocations in Leukemia"*
**作者**：Miller, A. et al.
**摘要**：研究开发了一种特异性识别ETV6蛋白的单克隆抗体，用于通过免疫荧光和Western blot检测ETV6-RUNX1等融合蛋白，为白血病分子诊断提供新工具。
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2. **标题**：*"ETV6 Expression Loss in Myelodysplastic Syndromes: An Immunohistochemical Study"*
**作者**：Chen, L. et al.
**摘要**：通过免疫组化分析骨髓增生异常综合征患者样本，发现ETV6抗体能有效标记ETV6蛋白缺失，提示其可作为疾病分型的潜在标志物。
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3. **标题**：*"Validation of ETV6 Antibodies in Pediatric Solid Tumors with ETV6-NTRK3 Fusions"*
**作者**：Kim, J. & Rodriguez, S.
**摘要**：验证了商用ETV6抗体在儿童实体瘤(如先天性纤维肉瘤)中对ETV6-NTRK3融合蛋白的检测效能，证明其与FISH结果高度一致。
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**备注**：实际文献需通过PubMed、Google Scholar等平台检索关键词如“ETV6 antibody diagnostic use”或“ETV6 immunohistochemistry”。建议优先选择近5年发表、高影响因子的期刊论文。
The ETV6 antibody is a crucial tool in studying the ETV6 protein (Ets variant 6), a transcription factor encoded by the *ETV6* gene located on human chromosome 12p13.2. ETV6 belongs to the ETS family of transcription regulators, characterized by a conserved ETS DNA-binding domain. It plays essential roles in hematopoiesis, embryonic development, and cellular differentiation by regulating gene expression through DNA binding and protein-protein interactions. Structurally, ETV6 contains an N-terminal pointed (PNT) domain, which mediates oligomerization, and a C-terminal ETS domain for DNA binding. Dysregulation of ETV6. particularly through chromosomal translocations (e.g., *ETV6-RUNX1* in pediatric B-cell acute lymphoblastic leukemia or *ETV6-NTRK3* in congenital fibrosarcoma), is implicated in various cancers, making it a significant biomarker in oncology research.
ETV6 antibodies are widely used in techniques like immunohistochemistry (IHC), Western blot (WB), and immunofluorescence (IF) to detect ETV6 expression, localization, and fusion proteins in clinical and research settings. These antibodies help identify ETV6-related oncogenic fusion products, aiding in cancer diagnosis, prognosis, and therapeutic targeting. However, challenges exist due to homology between ETV6 and other ETS family members, necessitating rigorous validation to ensure specificity. Research on ETV6 also extends to understanding its tumor-suppressive roles in certain contexts, such as modulating TGF-β signaling. Overall, ETV6 antibodies are indispensable for unraveling the dual roles of ETV6 in both normal physiology and disease pathogenesis.
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