Rabbit Monoclonal MYO7A Antibody

MYO7A antibodies target myosin VIIA, a motor protein encoded by the MYO7A gene, which belongs to the myosin superfamily involved in intracellular transport and mechanical processes. MYO7A is critical for normal function in sensory cells, particularly inner ear hair cells and retinal photoreceptors. Mutations in MYO7A are linked to Usher syndrome type 1B (USH1B), characterized by congenital deafness, balance disorders, and progressive vision loss, as well as nonsyndromic hearing loss (DFNB2/DFNA11). The protein's structure includes an N-terminal motor domain for actin binding and ATP hydrolysis, and a C-terminal FERM domain mediating protein interactions. MYO7A facilitates stereocilia elongation, melanosome transport in retinal pigment epithelium, and phagocytosis in photoreceptors. Antibodies against MYO7A are essential tools for studying its localization, expression, and functional roles in these tissues. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate pathogenic mechanisms in Usher syndrome or evaluate MYO7A-related therapeutic strategies. Both polyclonal and monoclonal antibodies are available, with applications ranging from detecting MYO7A in cell lysates to visualizing its distribution in tissue sections. These reagents contribute to advancing research on genetic hearing and vision disorders, aiding in diagnostics and molecular pathology studies.