| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DJ2; DjA1; DNAJ2; Dnaja1; HDJ2; HSDJ; HSJ2; HSPF4; NEDD7;;DNAJA1 |
| WB Predicted band size | 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human DNAJA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于DNAJA1抗体的3篇参考文献示例(示例为虚构内容，仅作格式参考)：
1. **文献名称**：DNAJA1 Expression in Hepatocellular Carcinoma: Prognostic Implications and Functional Analysis
**作者**：Li, X. et al.
**摘要**：研究通过免疫组化(使用抗DNAJA1抗体)和Western blot分析肝癌组织中DNAJA1的表达水平，发现其高表达与患者不良预后相关。体外实验表明，抑制DNAJA1可减少肿瘤细胞增殖和迁移。
2. **文献名称**：DNAJA1 Antibody Reveals Its Role in Protein Quality Control During Neurodegeneration
**作者**：Smith, J. & Wang, Y.
**摘要**：利用DNAJA1特异性抗体研究其在阿尔茨海默病模型中的定位，发现DNAJA1与错误折叠的Tau蛋白共定位，提示其可能通过Hsp70通路参与神经退行性疾病的蛋白稳态调控。
3. **文献名称**：DNAJA1 as a Biomarker for Chemoresistance in Breast Cancer: Validation via Immunohistochemistry
**作者**：Chen, L. et al.
**摘要**：通过抗DNAJA1抗体检测乳腺癌患者组织样本，证实DNAJA1高表达与化疗耐药性显著相关。机制研究表明，DNAJA1通过调控Bcl-2家族蛋白增强细胞存活。
(注：以上文献及摘要均为模拟生成，实际引用需查询真实数据库如PubMed、Web of Science等。)
DNAJA1 antibody is a tool used to detect DNAJA1. a member of the heat shock protein 40 (Hsp40/DNAJ) family. DNAJA1. also known as Hdj2 or DjA1. functions as a co-chaperone with Hsp70. assisting in protein folding, degradation, and stress response. It contains a conserved J-domain that regulates Hsp70’s ATPase activity, enabling substrate binding and refolding. DNAJA1 is implicated in cellular processes like apoptosis, autophagy, and mitochondrial homeostasis, and is expressed in both cytoplasmic and mitochondrial compartments.
Antibodies targeting DNAJA1 are widely used in research to study its role in diseases, particularly cancer. Overexpression of DNAJA1 has been observed in tumors, where it may promote cell proliferation, metastasis, and chemoresistance by stabilizing oncoproteins (e.g., mutant p53). Conversely, reduced DNAJA1 levels correlate with neurodegenerative disorders like Parkinson’s disease, reflecting its role in protein quality control.
These antibodies are validated for techniques like Western blotting, immunoprecipitation, and immunofluorescence. Commercial DNAJA1 antibodies are often raised against specific epitopes (e.g., human DNAJA1 N-terminal or C-terminal regions) and tested for cross-reactivity across species (human, mouse, rat). Researchers use them to explore DNAJA1’s interaction networks, subcellular localization, and regulatory mechanisms under stress conditions. Variants or post-translational modifications of DNAJA1 are also investigated using isoform-specific antibodies.
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