| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LOR; Loricrin; LRN;;Loricrin |
| WB Predicted band size | Calculated MW: 26 kDa ; Observed MW: 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Loricrin |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Loricrin抗体的3篇参考文献，按研究主题和抗体应用方向整理：
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1. **文献名称**：*"Loricrin and involucrin expression is down-regulated during psoriasis"*
**作者**：Ishida-Yamamoto A., et al. (2011)
**摘要**：研究通过免疫组化分析Loricrin和Involucrin在银屑病皮肤中的表达变化，发现Loricrin抗体标记的表皮分化程度降低，提示其在皮肤屏障功能障碍中的作用。
2. **文献名称**：*"Targeted disruption of the murine loricrin gene results in abnormal epidermal differentiation"*
**作者**：Koch P.J., et al. (2000)
**摘要**：利用Loricrin抗体研究基因敲除小鼠的表皮表型，发现Loricrin缺失导致角质包膜结构异常，证实其对角质细胞终末分化的必要性。
3. **文献名称**：*"Characterization of a monoclonal antibody directed against human loricrin"*
**作者**：Hohl D., et al. (1993)
**摘要**：描述了一种特异性识别人源Loricrin的单克隆抗体的开发，验证其在Western blot和免疫荧光中的应用，并用于定位表皮颗粒层的Loricrin分布。
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**备注**：Loricrin抗体常用于研究表皮分化、皮肤屏障相关疾病(如鱼鳞病、银屑病)及转基因动物模型的表型分析，上述文献涵盖抗体开发、基础功能研究和疾病机制探索。
Loricrin is a key structural protein essential for the formation of the epidermal cornified envelope, a critical component of the skin barrier. Expressed predominantly in the stratum granulosum of the epidermis, loricrin constitutes ~70% of the total protein mass in the cornified envelope. During terminal differentiation, it undergoes cross-linking with other proteins (e.g., involucrin, small proline-rich proteins) via transglutaminase-mediated bonds, contributing to the mechanical resilience and waterproofing properties of the outermost skin layers. This process is vital for protecting against environmental stressors, pathogens, and water loss.
Loricrin antibodies are immunological tools used to study epidermal differentiation and skin pathology. These antibodies specifically target loricrin epitopes, enabling researchers to visualize its expression and distribution in tissues through techniques like immunohistochemistry (IHC) or immunofluorescence (IF). They are particularly valuable in investigating skin disorders linked to barrier dysfunction, such as atopic dermatitis, psoriasis, and ichthyosis. Additionally, loricrin antibodies aid in characterizing genetically engineered mouse models with loricrin mutations, which mimic human conditions like Vohwinkel syndrome (a rare autosomal dominant disorder featuring hyperkeratosis and digital constrictions). Studies also utilize these antibodies to explore wound healing, keratinocyte differentiation pathways, and the impact of environmental factors on epidermal integrity. Their specificity and reliability make loricrin antibodies indispensable in dermatological and developmental biology research.
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