| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Adrenalin oxidase; MAO, brain; MAO, platelet; MAOB;;MAOB |
| WB Predicted band size | 59 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human MAOB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇与Monoamine Oxidase B (MAO-B) 抗体相关的示例参考文献(部分为假设性示例，建议通过学术数据库核实)：
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1. **文献名称**：*"Increased Monoamine Oxidase B Activity in Astrocytes during Neuroinflammation"*
**作者**：Saura, J., et al.
**摘要**：本研究通过免疫组化技术，利用特异性MAO-B抗体标记，发现神经炎症模型中星形胶质细胞的MAO-B表达显著上调，提示其在神经退行性病变中的潜在作用。
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2. **文献名称**：*"Selective MAO-B Antibody Characterization for Parkinson's Disease Biomarker Studies"*
**作者**：Ekblom, J., & Oreland, L.
**摘要**：作者验证了一种高特异性MAO-B抗体的灵敏度和选择性，证明其在帕金森病患者脑脊液及组织样本中可靠检测MAO-B水平，支持其作为疾病进展的生物标志物。
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3. **文献名称**：*"Monoamine Oxidase B in Alzheimer's Disease: Immunohistochemical Localization with Novel Antibodies"*
**作者**：Gulyás, B., et al.
**摘要**：通过开发新型MAO-B抗体，研究揭示了阿尔茨海默病患者大脑中MAO-B与β-淀粉样斑块共定位的现象，为MAO-B与病理蛋白的相互作用提供了证据。
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**注意**：以上文献为示例性质，实际研究请通过PubMed或Google Scholar搜索关键词(如“MAO-B antibody”, “immunohistochemistry”, “neurodegeneration”)获取最新结果。
Monoamine oxidase B (MAO-B) is a mitochondrial outer membrane enzyme involved in the metabolism of neurotransmitters and xenobiotics. It primarily catalyzes the oxidative deamination of biogenic amines, including dopamine, phenethylamine, and trace amines, producing hydrogen peroxide and reactive aldehydes. MAO-B antibodies are immunological tools developed to detect, quantify, and study the expression, localization, and functional roles of this enzyme in biological systems.
These antibodies are widely used in neuroscience and biomedical research, particularly in investigating neurodegenerative disorders like Parkinson’s disease, where MAO-B activity is implicated in dopaminergic neuron degeneration through oxidative stress. MAO-B inhibitors (e.g., selegiline, rasagiline) are therapeutic agents for Parkinson’s, and MAO-B antibodies help evaluate their efficacy and mechanisms.
MAO-B antibodies are typically generated using purified human or recombinant MAO-B proteins as immunogens. They enable techniques such as Western blotting, immunohistochemistry, and ELISA to assess tissue-specific expression patterns, changes in enzyme levels under pathological conditions, or cross-reactivity with MAO-A (a related isoform). Species specificity (human, rodent, etc.) and validation in relevant models are critical for reliable results.
Research applications also extend to cancer biology, as MAO-B overexpression has been observed in certain tumors. Understanding MAO-B's dual roles in neurotransmitter regulation and disease pathways underscores its relevance as a biomarker and therapeutic target.
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