Rabbit Monoclonal MonoamineOxidaseA Antibody

The Monoamine Oxidase A (MAO-A) antibody is a crucial tool in neuroscience and biochemical research, targeting the MAO-A enzyme, a key regulator of neurotransmitter metabolism. MAO-A catalyzes the oxidative deamination of monoamine neurotransmitters, including serotonin, norepinephrine, and dopamine, modulating their availability in the central nervous system and peripheral tissues. Dysregulation of MAO-A activity has been linked to neuropsychiatric disorders such as depression, anxiety, and neurodegenerative diseases. Researchers employ MAO-A antibodies in techniques like Western blotting, immunohistochemistry, and ELISA to quantify protein expression, assess tissue distribution, and investigate its role in disease pathways. These antibodies help identify altered MAO-A levels in brain regions or peripheral samples, offering insights into mechanisms underlying mood disorders or responses to pharmacological agents. Genetic studies also utilize MAO-A antibodies to explore associations between MAOA gene polymorphisms (e.g., the "warrior gene" variant) and behavioral phenotypes. Additionally, MAO-A inhibitors are used as antidepressants, making these antibodies valuable for evaluating drug efficacy and target engagement in preclinical models. Specificity validation via knockout controls ensures reliable detection, supporting both diagnostic research and therapeutic development. Overall, MAO-A antibodies bridge molecular insights with clinical applications in neurology and psychiatry.