| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AREI; cstA; Cystatin A; Cystatin AS; Stefin A; STF1; STFA;;Cystatin A |
| WB Predicted band size | Calculated MW: 11 kDa ; Observed MW: 13 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Cystatin A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Cystatin A抗体的3篇代表性文献的简要信息(文献标题和内容为模拟概括，仅供参考)：
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1. **文献名称**: *Cystatin A as a potential biomarker in head and neck squamous cell carcinoma*
**作者**: Smith J, et al.
**摘要**: 本研究通过免疫组化(IHC)和Western blot技术验证了Cystatin A抗体在头颈鳞状细胞癌组织中的特异性表达，发现其高表达与肿瘤侵袭性相关，提示其作为诊断标志物的潜力。
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2. **文献名称**: *Development and validation of a monoclonal antibody against human Cystatin A for dermatopathological applications*
**作者**: Lee H, et al.
**摘要**: 报道了一种高特异性抗人Cystatin A单克隆抗体的开发，通过ELISA和免疫荧光验证其在银屑病和皮肤癌组织中的定位，证明该抗体可用于皮肤疾病病理机制研究。
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3. **文献名称**: *Cystatin A expression in tumor-associated macrophages: Insights from antibody-based profiling*
**作者**: Garcia R, et al.
**摘要**: 利用Cystatin A抗体分析肿瘤微环境中巨噬细胞的表达模式，发现其与肿瘤免疫抑制微环境相关，为癌症免疫治疗提供新靶点。
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如需具体文献，建议在PubMed或Web of Science中检索关键词：**Cystatin A antibody**、**CSTA immunohistochemistry** 或 **Stefin A (Cystatin A) biomarker**，并筛选近5-10年的研究论文。
Cystatin A, also known as stefin A, is a member of the cystatin superfamily of cysteine protease inhibitors. It primarily regulates the activity of cysteine proteases, such as cathepsins B, H, and L, by blocking their enzymatic function, thereby maintaining protease-antiprotease balance in tissues. This 11 kDa intracellular protein is expressed in various epithelial and immune cells, playing roles in cell proliferation, differentiation, apoptosis, and immune modulation. Dysregulation of cystatin A has been implicated in pathological conditions, including cancer, neurodegenerative disorders, and inflammatory diseases, where uncontrolled protease activity contributes to tissue damage or disease progression.
Antibodies targeting cystatin A are essential tools for investigating its biological functions and clinical relevance. They enable the detection and quantification of cystatin A expression in tissues and bodily fluids using techniques like Western blotting, immunohistochemistry, and ELISA. These antibodies have been employed to study its downregulation in certain cancers (e.g., squamous cell carcinoma) or accumulation in amyloid deposits in neurodegenerative conditions. Both monoclonal and polyclonal anti-cystatin A antibodies are available, with specific applications depending on required sensitivity and experimental design. Recent research also explores their potential diagnostic utility, particularly in cancer biomarker panels or inflammatory disease monitoring. However, interpretation requires caution due to cross-reactivity risks with homologous cystatin family members in some antibody preparations.
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