| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AMDM; ANPB; ANPRB; GCB; GUC2B; GUCY2B; Npr2; NPRB; NPRBi;;NPR2 |
| WB Predicted band size | 117 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human NPR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3条关于ANPRB(心房钠尿肽受体B型，即NPR-B)抗体的模拟参考文献示例(非真实文献，仅供格式参考)：
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1. **文献名称**: *Development of a High-Specificity Monoclonal Antibody for NPR-B Detection in Cardiovascular Tissues*
**作者**: Smith J, et al.
**摘要**: 本研究报道了一种针对NPR-B胞外域的单克隆抗体的开发与验证。该抗体通过免疫组化与Western blot证实了其在心脏、血管内皮等组织中的高特异性，为心血管疾病中NPR-B表达水平分析提供了可靠工具。
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2. **文献名称**: *NPR-B Antibody Reveals Receptor Localization in Renal Tubules and Blood Pressure Regulation*
**作者**: Lee H, et al.
**摘要**: 通过免疫荧光技术结合NPR-B特异性抗体，作者揭示了该受体在肾脏远端小管中的分布特征，并发现其在盐敏感性高血压模型中表达下调，提示其参与体液平衡与血压调控的分子机制。
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3. **文献名称**: *Targeting NPR-B with Neutralizing Antibody Attenuates Cardiac Hypertrophy in Experimental Models*
**作者**: Zhang R, et al.
**摘要**: 研究利用中和性NPR-B抗体，在心肌细胞肥大模型中验证了阻断受体活性可抑制ANP介导的cGMP信号通路，显著减轻病理性心脏重塑，为心衰治疗提供了潜在策略。
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**注**：以上文献为示例性内容，实际引用时需检索真实数据库(如PubMed、Web of Science)获取权威研究。若需具体文献推荐，可提供研究背景或补充关键词。
**Background of ANPRB Antibody**
The ANPRB antibody targets the atrial natriuretic peptide receptor B (ANPRB), also known as natriuretic peptide receptor B (NPR-B) or NPR2. a transmembrane guanylyl cyclase receptor primarily activated by C-type natriuretic peptide (CNP). NPR-B plays a critical role in regulating cardiovascular homeostasis, bone growth, and cellular proliferation through the production of cyclic guanosine monophosphate (cGMP), which mediates downstream signaling pathways.
NPR-B is structurally characterized by an extracellular ligand-binding domain, a single transmembrane helix, and an intracellular guanylyl cyclase domain. Dysregulation of NPR-B signaling is linked to pathologies such as skeletal dysplasia (e.g., short-limbed dwarfism), hypertension, and heart failure. ANPRB antibodies are essential tools in biomedical research for detecting NPR-B expression, studying its physiological roles, and exploring its involvement in disease mechanisms.
These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to assess receptor localization, expression levels, and activation status in tissues or cell lines. Research utilizing ANPRB antibodies has advanced understanding of CNP/NPR-B signaling in vascular remodeling, endochondral ossification, and cancer progression. Their application also supports drug discovery efforts aimed at modulating NPR-B activity for therapeutic interventions.
Overall, ANPRB antibodies are pivotal in elucidating the complex roles of NPR-B in health and disease, bridging molecular insights with clinical relevance.
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