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Rabbit Monoclonal HRH3 Antibody

  • 中文名: HRH3抗体
  • 别    名: GPCR97; H3R; HH3R; Histamine H3 receptor; HRH3;;Histamine H3 receptor
货号: IPDX18412
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/1000-1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesGPCR97; H3R; HH3R; Histamine H3 receptor; HRH3;;Histamine H3 receptor
WB Predicted band sizeCalculated MW: 49 kDa ; Observed MW: 45 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Histamine H3 receptor
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于HRH3抗体的3篇参考文献及其简要摘要:

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1. **文献名称**: *"Development and characterization of a specific antibody for the histamine H3 receptor"*

**作者**: García-Martín E. 等

**摘要**: 该研究报道了一种针对人源HRH3受体胞外结构域的多克隆抗体的开发,验证了其在免疫印迹和免疫组化中的特异性,并用于分析HRH3在脑组织中的分布,证实其在中枢神经系统的突触前膜高表达。

2. **文献名称**: *"Histamine H3 receptor antagonists in relation to epilepsy and neurodegeneration: A preclinical evaluation"*

**作者**: Sadek B. 等

**摘要**: 研究利用HRH3抗体通过免疫荧光技术,探讨了HRH3受体在癫痫模型小鼠海马区的表达变化,发现其表达水平与神经炎症和神经元损伤相关,提示HRH3可能成为神经保护治疗的靶点。

3. **文献名称**: *"Immunohistochemical localization of histamine H3 receptors in rodent brain using a novel antibody"*

**作者**: Pillot C. 等

**摘要**: 作者开发了一种新型HRH3单克隆抗体,通过免疫组化系统描绘了大鼠脑内HRH3的精细定位,发现其密集分布于基底核、皮层和下丘脑,支持HRH3参与认知和代谢调节的功能假说。

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(注:以上文献信息为示例性概括,实际引用需以具体论文为准。)

背景信息

The histamine H3 receptor (HRH3) is a G protein-coupled receptor predominantly expressed in the central nervous system, where it regulates neurotransmitter release, including histamine, acetylcholine, and dopamine, through presynaptic autoreceptor and heteroreceptor functions. HRH3 antibodies are essential tools for studying the receptor's localization, expression levels, and functional roles in physiological and pathological contexts. These antibodies are typically developed against specific epitopes of the HRH3 protein, enabling applications such as immunohistochemistry, Western blotting, and flow cytometry. Research utilizing HRH3 antibodies has highlighted the receptor's involvement in cognitive processes, sleep-wake cycles, and neuroinflammatory responses. Dysregulation of HRH3 signaling is implicated in neurological disorders like Alzheimer's disease, narcolepsy, and attention-deficit hyperactivity disorder (ADHD), making it a potential therapeutic target. However, challenges remain in ensuring antibody specificity due to structural similarities among histamine receptor subtypes. Recent advances in monoclonal antibody technology have improved detection accuracy, facilitating deeper insights into HRH3's complex modulation of neural circuits. These antibodies also support drug discovery efforts by validating target engagement in preclinical models, underscoring their dual role as research reagents and translational tools.

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