| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Adam15; MDC15; Metargidin;;ADAM 15 |
| WB Predicted band size | Calculated MW: 93 kDa ; Observed MW: 90,100 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human ADAM 15 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于ADAM15抗体的3篇参考文献示例(内容基于公开研究概括，非真实文献)：
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1. **文献名称**: *ADAM15 promotes tumor progression and metastasis through integrin-mediated signaling in breast cancer*
**作者**: Smith, J.R., et al.
**摘要**: 研究揭示了ADAM15在乳腺癌细胞中的高表达，其通过与β1整合素相互作用增强肿瘤细胞迁移和侵袭。使用特异性ADAM15抗体阻断实验，证实其在调控细胞外基质降解和转移中的关键作用。
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2. **文献名称**: *ADAM15 regulates endothelial permeability and angiogenesis via proteolytic shedding of VE-cadherin*
**作者**: Lee, H., et al.
**摘要**: 该文献利用ADAM15中和抗体，证明ADAM15通过切割VE-钙黏蛋白破坏血管内皮屏障功能，促进血管生成。研究为靶向ADAM15治疗病理性血管疾病提供了依据。
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3. **文献名称**: *ADAM15 as a therapeutic target in inflammatory arthritis: Insights from antibody-mediated inhibition studies*
**作者**: Müller-Ladner, U., et al.
**摘要**: 研究通过ADAM15抗体抑制实验，发现ADAM15在类风湿性关节炎滑膜细胞中异常活化，促进炎症因子释放和关节破坏，提示其作为抗炎治疗的潜在靶点。
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如需具体文献，建议通过PubMed或Web of Science检索关键词“ADAM15 antibody”获取最新研究。
ADAM15 (A Disintegrin And Metalloproteinase 15) is a member of the ADAM family of transmembrane proteins, which are involved in cell-cell signaling, adhesion, and proteolytic processing of substrates. Structurally, ADAM15 contains conserved domains, including a prodomain, metalloproteinase, disintegrin-like, cysteine-rich, epidermal growth factor (EGF)-like, transmembrane, and cytoplasmic tail regions. It is expressed in various tissues, particularly in endothelial cells, smooth muscle cells, and certain cancer cells. ADAM15 has been implicated in pathological processes such as inflammation, angiogenesis, and tumor progression due to its roles in extracellular matrix remodeling, growth factor shedding, and integrin-mediated signaling.
Antibodies targeting ADAM15 are essential tools for studying its expression, localization, and function. These antibodies enable detection of ADAM15 in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry, aiding research into its involvement in diseases. For instance, elevated ADAM15 levels correlate with cancer metastasis and arthritis, making it a potential biomarker or therapeutic target. Commercial ADAM15 antibodies are often raised against specific epitopes (e.g., the cytoplasmic domain) and validated for species cross-reactivity (human, mouse, rat). Researchers utilize these antibodies to explore ADAM15's dual roles in promoting cell adhesion via disintegrin domains and matrix degradation via metalloproteinase activity, offering insights into its complex contributions to disease mechanisms.
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