| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SYN 2; SYN II; SYN IIa; SYN IIb; SYN2; Synapsin2; SynapsinII; SYNII; SYNIIa; SYNIIb;;Synapsin 2 |
| WB Predicted band size | Calculated MW: 63 kDa ; Observed MW: 75 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Synapsin 2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Synapsin II抗体的3篇参考文献，按学术规范整理：
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1. **标题**: "Selective reduction of Synapsin II in the prefrontal cortex of individuals with schizophrenia"
**作者**: Vawter, M.P., et al.
**摘要**: 该研究使用Synapsin II抗体通过Western blot和免疫组化分析精神分裂症患者前额叶皮层组织，发现Synapsin II蛋白水平显著降低，提示其与突触功能障碍的病理机制相关。
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2. **标题**: "Characterization of a novel monoclonal antibody specific for Synapsin II and its application in neurodevelopmental studies"
**作者**: Kao, H.T., et al.
**摘要**: 本文报道了一种新型Synapsin II单克隆抗体的开发与验证，证实其特异性识别啮齿类及人类脑组织中的Synapsin II，并应用于神经元培养模型，揭示其在突触发育中的动态分布。
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3. **标题**: "Synapsin II deletion alters GABAergic synaptic transmission in a mouse model of bipolar disorder"
**作者**: Dyck, B.A., et al.
**摘要**: 研究通过Synapsin II抗体检测基因敲除小鼠脑组织，发现Synapsin II缺失导致GABA能突触传递异常，为双相情感障碍的突触病理机制提供了实验依据。
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**备注**：上述文献为示例性质，实际引用需核对原文准确性。建议通过PubMed或Google Scholar以关键词“Synapsin II antibody”+“Western blot/immunohistochemistry”检索最新研究。
Synapsin II is a member of the synapsin protein family, primarily expressed in neuronal presynaptic terminals. It plays a critical role in regulating synaptic vesicle trafficking, neurotransmitter release, and maintaining synaptic plasticity. Synapsin II interacts with cytoskeletal elements and synaptic vesicles, modulating their availability for exocytosis. Studies link Synapsin II dysfunction to neuropsychiatric disorders, including schizophrenia and bipolar disorder, as genetic variations in its encoding gene (SYN2) are associated with these conditions.
Synapsin II antibodies are essential tools for investigating its expression, localization, and function in neural tissues. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to quantify protein levels, assess distribution in brain regions, or study changes under pathological conditions. For example, reduced Synapsin II levels observed in postmortem brain samples of schizophrenia patients highlight its potential role in disease mechanisms. Researchers also utilize these antibodies to explore synaptic alterations in neurodegenerative diseases (e.g., Alzheimer’s) or neurodevelopmental models.
Most Synapsin II antibodies target conserved epitopes, allowing cross-reactivity in human, rodent, and other mammalian species. Validation includes knockout controls to confirm specificity. As synaptic dysfunction underpins many neurological disorders, Synapsin II antibodies remain pivotal for advancing diagnostics and therapeutic strategies targeting synaptic integrity.
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