Rabbit Monoclonal HOXA5 Antibody

The HOXA5 antibody is a crucial tool for studying the HOXA5 protein, a member of the homeobox (HOX) gene family, which plays essential roles in embryonic development, cellular differentiation, and tissue patterning. HOXA5. located on chromosome 7p15.2. encodes a transcription factor that regulates gene expression by binding to specific DNA sequences, influencing processes such as organogenesis, particularly in the lungs, gastrointestinal tract, and mammary glands. Dysregulation of HOXA5 has been implicated in various cancers, including breast, colorectal, and lung cancers, where its loss or reduced expression correlates with tumor progression, metastasis, and poor prognosis. HOXA5 antibodies are widely used in research to detect and quantify HOXA5 protein levels via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help elucidate HOXA5's role in normal development and disease, including its tumor-suppressive functions and interactions with signaling pathways like Wnt and TGF-β. Validated HOXA5 antibodies exhibit high specificity, often confirmed through knockout controls or siRNA-mediated gene silencing. Their applications extend to studying epigenetic regulation, such as DNA methylation-mediated HOXA5 silencing in cancer, and exploring therapeutic strategies targeting HOXA5 reactivation. Researchers also utilize these antibodies in developmental biology models to map HOXA5 expression patterns, providing insights into congenital disorders and regenerative medicine approaches.