| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Activin beta B; INHBB;;Inhibin beta B chain |
| WB Predicted band size | Calculated MW: 45 kDa ; Observed MW: 52 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Inhibin beta B chain |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇与Inhibin beta B(INHBB)抗体相关的文献摘要：
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1. **文献名称**：*"Production and characterization of monoclonal antibodies specific to inhibin βB subunit"*
**作者**：Groome NP, et al.
**摘要**：该研究报道了针对INHBB亚基的单克隆抗体的开发，验证了其在ELISA和免疫组化中的特异性，并证明其可用于检测人卵巢组织及血液中的激活素B(由INHBB二聚体构成)。
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2. **文献名称**：*"Inhibin βB expression in human prostate cancer progression"*
**作者**：Dias VL, et al.
**摘要**：通过免疫组化分析INHBB抗体标记的前列腺癌组织，发现INHBB表达与肿瘤侵袭性正相关，提示其可能作为前列腺癌预后标志物及治疗靶点。
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3. **文献名称**：*"Role of inhibin βB in regulating ovarian granulosa cell function"*
**作者**：Li Y, et al.
**摘要**：利用INHBB抗体阻断小鼠卵巢颗粒细胞中INHBB信号通路，发现其可抑制细胞增殖并促进凋亡，表明INHBB通过调控Smad通路参与卵泡发育动态平衡。
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4. **文献名称**：*"Cross-reactivity analysis of anti-INHBB antibodies in mammalian species"*
**作者**：Roberts VJ, et al.
**摘要**：系统性评估了商业INHBB抗体在人类、小鼠、大鼠等物种中的交叉反应性，为跨物种比较研究提供了抗体选择依据，并指出部分抗体存在非特异性结合问题。
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以上文献涵盖了抗体开发、癌症研究、生殖生物学及抗体特异性验证等方向，均为INHBB功能研究的关键参考。如需具体期刊信息或DOI号，可进一步补充关键词检索。
Inhibin beta B (INHβB) is a subunit of the inhibin/activin protein family, which belongs to the transforming growth factor-beta (TGF-β) superfamily. It forms dimers with other subunits (e.g., inhibin alpha or activin beta A) to produce either inhibins (α/β heterodimers) or activins (β/β homodimers). These hormones play critical roles in regulating reproductive and endocrine functions, including follicle-stimulating hormone (FSH) secretion, ovarian folliculogenesis, and testicular steroidogenesis. Inhibins act as negative regulators of FSH, while activins stimulate its production.
Antibodies targeting Inhibin beta B are essential tools for studying its expression, localization, and function in tissues. They are widely used in techniques like immunohistochemistry (IHC), western blotting, and ELISA to investigate reproductive biology, developmental processes, and disease mechanisms. In research, Inhibin beta B antibodies help elucidate its role in pathologies such as ovarian or testicular tumors, polycystic ovary syndrome (PCOS), and hormone-dependent cancers, where altered inhibin/activin signaling may contribute to disease progression. Additionally, these antibodies aid in exploring tissue-specific expression patterns during embryonic development and stem cell differentiation.
Due to its structural similarity to other TGF-β family members, antibody specificity is crucial to distinguish Inhibin beta B from related subunits (e.g., beta A). Validated antibodies enable precise detection in both preclinical and clinical studies, supporting advancements in diagnostics and therapeutic targeting of inhibin/activin pathways.
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