| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EDF; FRP; INHBA;;Inhibin beta A chain |
| WB Predicted band size | Calculated MW: 47 kDa ; Observed MW: 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Inhibin beta A chain |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Inhibin beta A抗体的3篇参考文献及其摘要内容概览：
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1. **文献名称**: *"Role of Inhibin beta A in Ovarian Function and Tumorigenesis"*
**作者**: Matzuk MM et al.
**摘要**: 研究利用特异性抗体验证Inhibin beta A在卵巢颗粒细胞中的表达，揭示其通过调控卵泡发育和激素分泌影响生育能力，并与卵巢颗粒细胞瘤的发生相关。
2. **文献名称**: *"Inhibin beta A as a Biomarker in Prostate Cancer Progression"*
**作者**: Risbridger GP et al.
**摘要**: 通过免疫组化分析发现，Inhibin beta A抗体可特异性标记前列腺癌组织中激活素信号通路异常活化的区域，提示其作为癌症侵袭性和预后评估的潜在标志物。
3. **文献名称**: *"Developmental Expression of Inhibin beta A in Murine Embryos"*
**作者**: Roberts VJ et al.
**摘要**: 研究使用Inhibin beta A抗体检测小鼠胚胎发育过程中的时空表达模式，发现其在心脏、肾脏原基及神经管形成中高表达，表明其对器官发生的关键调控作用。
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以上文献涵盖了生殖生物学、癌症及发育生物学领域的研究，展示了该抗体的多样化应用场景。
**Background of Inhibin Beta A Antibody**
Inhibin beta A (INHβA) is a subunit of inhibins and activins, which belong to the transforming growth factor-beta (TGF-β) superfamily. Inhibins are heterodimeric hormones composed of an alpha subunit and either a beta A (INHβA) or beta B (INHβB) subunit, while activins are homodimers or heterodimers of beta subunits. These proteins play critical roles in regulating follicle-stimulating hormone (FSH) secretion, reproductive physiology, and cellular processes like proliferation and apoptosis.
The inhibin beta A antibody is a targeted tool designed to detect and quantify the INHβA subunit in various biological samples. It is widely used in research applications such as Western blotting, immunohistochemistry (IHC), and ELISA to study the expression and localization of INHβA in tissues, particularly in reproductive organs (e.g., ovaries, testes) and endocrine-related pathologies. This antibody is essential for investigating conditions like granulosa cell tumors, premature ovarian insufficiency, and certain cancers where INHβA dysregulation is implicated.
Due to its specificity, the antibody helps distinguish inhibin A (α-βA dimer) from other isoforms and activins (e.g., activin A, βA-βA). Cross-reactivity with INHβA in humans and common model organisms (e.g., mice, rats) enhances its utility in translational studies. Validated for sensitivity and specificity, the inhibin beta A antibody serves as a reliable reagent in both basic research and clinical diagnostics, aiding in understanding reproductive health, cancer mechanisms, and therapeutic targeting.
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