| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HLA B; HLAB;;HLA B |
| WB Predicted band size | 40 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human HLA B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于HLA-B7抗体的3篇参考文献摘要示例(注：文献为模拟示例，非真实存在)：
1. **文献名称**：*HLA-B7 Antibodies in Renal Transplant Rejection*
**作者**：Smith J, et al.
**摘要**：探讨HLA-B7抗体在肾移植排斥反应中的作用，发现患者体内预存的HLA-B7抗体与移植后急性排斥风险显著相关，提示术前抗体筛查的重要性。
2. **文献名称**：*Detection and Clinical Impact of Anti-HLA-B7 Antibodies in Transfusion Recipients*
**作者**：Lee S, et al.
**摘要**：分析输血患者中HLA-B7抗体的检出率及其对输血反应的关联，提出HLA-B7抗体可能引发非溶血性发热反应，需优化血制品匹配策略。
3. **文献名称**：*HLA-B7 Antibody Characterization via Luminex-based Assays*
**作者**：Garcia R, et al.
**摘要**：利用Luminex单抗原微珠技术对HLA-B7抗体进行高灵敏度检测，验证其在临床实验室中的可靠性和对移植配型的指导价值。
如需真实文献，建议通过PubMed或Google Scholar搜索关键词“HLA-B7 antibody”获取最新研究。
The HLA-B7 antibody is associated with the human leukocyte antigen (HLA) class I molecule HLA-B7. a key component of the major histocompatibility complex (MHC) involved in immune regulation. HLA-B7 is a cell surface glycoprotein responsible for presenting peptide antigens to CD8+ T cells, triggering immune responses against infected or abnormal cells. The HLA-B7 allele is prevalent in certain populations and has been linked to both protective and pathogenic roles in diseases. For instance, it is associated with increased susceptibility to conditions like ankylosing spondylitis, HIV progression, and hypersensitivity reactions to specific drugs (e.g., abacavir).
Antibodies targeting HLA-B7 are primarily studied in transplant medicine, as they can mediate graft rejection by recognizing mismatched HLA antigens on donor tissues. In autoimmune contexts, anti-HLA-B7 antibodies may contribute to tissue damage, though their role is less defined. These antibodies are detected via techniques such as flow cytometry, Luminex-based assays, or ELISA, which assess donor-recipient compatibility or diagnose antibody-mediated immune responses.
Research also explores HLA-B7's role in vaccine development and infectious diseases, as its antigen-presenting function influences pathogen-specific T-cell immunity. However, the clinical significance of HLA-B7 antibodies varies, emphasizing the need for personalized approaches in transplantation and immunotherapy. Their presence underscores the balance between immune surveillance and pathological reactivity, highlighting HLA-B7's dual role in health and disease.
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