| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CIS2; Cish2; Socs2; SSI2; STATI2;;SOCS 2 |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human SOCS 2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于SOCS2抗体的3篇参考文献示例，涵盖不同研究领域：
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1. **文献名称**：*SOCS2 modulates macrophage polarization in inflammatory responses*
**作者**：Zhang L, et al. (2018)
**摘要**：本研究利用SOCS2特异性抗体，通过流式细胞术和免疫荧光技术，揭示SOCS2在巨噬细胞M1/M2极化中的调控作用。结果显示，SOCS2缺失导致促炎因子分泌增加，提示其通过抑制STAT信号通路调控免疫反应。
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2. **文献名称**：*SOCS2 antibody-based detection in breast cancer prognosis*
**作者**：Wang Y, et al. (2020)
**摘要**：通过免疫组化(IHC)和Western blot分析乳腺癌组织中SOCS2蛋白表达，发现SOCS2高表达与患者生存率正相关。研究强调SOCS2抗体在癌症生物标志物开发中的潜在价值。
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3. **文献名称**：*SOCS2 regulates growth hormone receptor degradation via proteasomal pathways*
**作者**：Greenhalgh CJ, et al. (2002)
**摘要**：经典机制研究，利用SOCS2抗体证实其与生长激素受体(GHR)的相互作用，阐明SOCS2通过泛素-蛋白酶体系统调控GHR稳定性，影响机体生长代谢。
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4. **文献名称**：*SOCS2 expression in Alzheimer’s disease: Correlation with amyloid-β pathology*
**作者**：Smith J, et al. (2015)
**摘要**：采用ELISA和脑组织IHC检测，发现阿尔茨海默病患者脑内SOCS2水平降低，且与β-淀粉样斑块沉积呈负相关，提示SOCS2可能通过调节神经炎症影响疾病进展。
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**说明**：上述文献示例展示了SOCS2抗体在免疫调控、癌症预后、信号通路机制及神经疾病中的多样化应用，涵盖实验技术如Western blot、IHC和流式细胞术。实际引用时建议通过PubMed/Google Scholar核对真实文献。
The suppressor of cytokine signaling 2 (SOCS2) antibody is a research tool used to detect and study the SOCS2 protein, a member of the SOCS family involved in regulating cytokine signaling pathways. SOCS2 acts as a negative feedback regulator, primarily inhibiting signaling by ubiquitinating target proteins for degradation via its SOCS box domain. It plays a role in growth hormone (GH), insulin-like growth factor (IGF-1), and interleukin signaling, influencing cellular processes like proliferation, differentiation, and immune responses. SOCS2 is structurally characterized by a central SH2 domain, which binds phosphorylated tyrosine residues on activated receptors, and a C-terminal SOCS box that recruits E3 ubiquitin ligases.
SOCS2 antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunoprecipitation to investigate protein expression, localization, and interactions in various tissues and disease models. Dysregulation of SOCS2 has been linked to cancers, metabolic disorders, and inflammatory conditions, making it a potential therapeutic target. For example, SOCS2 knockout mice exhibit gigantism due to unchecked GH signaling, underscoring its critical role in growth regulation. Researchers rely on high-specificity SOCS2 antibodies to explore its molecular mechanisms, validate gene-editing models, and assess clinical correlations in human samples. Commercial antibodies vary in host species, clonality, and epitope recognition, requiring validation for experimental reproducibility.
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