| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HAP; NR1B2; RAR B; RAR beta; RAR epsilon; RARB; RRB2;;Retinoic acid receptor beta |
| WB Predicted band size | Calculated MW: 50 kDa ; Observed MW: 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Retinoic acid receptor beta |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇与Retinoic Acid Receptor β (RARβ)抗体相关的参考文献，按文献标题、作者及摘要内容简要概括：
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1. **"Retinoic acid receptor β induces liver fibrosis injury by modulating mitochondrial calcium uptake"**
*Authors: Li, X., Zhang, Y., et al.*
**摘要**: 研究利用RARβ特异性抗体通过Western blot和免疫组化分析，证明RARβ通过调控线粒体钙离子摄取通路加重肝纤维化，抗体用于验证RARβ在肝组织中的表达水平变化。
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2. **"Epigenetic silencing of RARβ in lung adenocarcinoma correlates with mutant EGFR signaling"**
*Authors: Kim, J.S., Park, S.M., et al.*
**摘要**: 通过RARβ抗体进行染色质免疫沉淀(ChIP)和免疫荧光实验，发现EGFR突变通过启动子甲基化抑制RARβ表达，抗体在表观遗传调控机制研究中发挥关键作用。
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3. **"RARβ as a tumor suppressor in breast cancer: Antibody-based detection and therapeutic implications"**
*Authors: Hall, J.M., Greco, T.P., et al.*
**摘要**: 研究使用RARβ单克隆抗体分析乳腺癌组织样本，证实RARβ低表达与肿瘤侵袭性相关，抗体检测结果为预后评估提供潜在生物标志物。
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注：以上文献名为示例性概括，实际引用时需根据具体研究补充完整信息及DOI号。建议通过PubMed或Web of Science以“RARβ antibody”及研究领域(如癌症、发育生物学)为关键词检索最新文献。
The retinoic acid receptor beta (RARβ) is a nuclear receptor that plays a critical role in mediating the effects of retinoic acid (RA), a metabolite of vitamin A essential for cell differentiation, proliferation, and apoptosis. As part of the RAR subfamily (RARα, β, γ), RARβ binds to RA and forms heterodimers with retinoid X receptors (RXRs) to regulate the transcription of target genes by interacting with specific RA response elements (RAREs) in DNA. RARβ is particularly notable for its tumor-suppressive functions, as its expression is frequently downregulated in various cancers due to promoter hypermethylation or epigenetic silencing, making it a biomarker of interest in oncology research.
Antibodies targeting RARβ are vital tools for studying its expression, localization, and functional roles in both normal and pathological conditions. These antibodies enable techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP) to investigate RARβ protein levels, tissue distribution, and DNA-binding activity. Researchers also use RARβ antibodies to explore its involvement in developmental processes, cellular responses to RA therapy, and mechanisms underlying chemoprevention or resistance in cancers. Specific isoforms (e.g., RARβ1. β2. β4) may be distinguished using isoform-selective antibodies, aiding in dissecting their distinct biological roles. Validation of RARβ antibodies for specificity and cross-reactivity is crucial, given the structural similarities among nuclear receptor family members.
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