| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BCAR 1; CAS; CAS1; Cass1; CRKAS; p130cas;;BCAR1 |
| WB Predicted band size | Calculated MW: 93 kDa ; Observed MW: 130 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human BCAR1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于BCAR1抗体的3篇代表性文献及其摘要概括：
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1. **文献名称**：*BCAR1/p130Cas Signaling in Endocrine-Resistant Breast Cancer*
**作者**：van Agthoven T, et al.
**摘要**：本研究利用BCAR1特异性抗体，通过免疫印迹和免疫荧光技术，揭示了BCAR1在乳腺癌内分泌治疗耐药中的作用。发现BCAR1过表达通过激活EGFR/Src信号通路促进细胞迁移和存活，提示其作为耐药标志物的潜力。
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2. **文献名称**：*The Role of p130Cas in Tumor Microenvironment Remodeling*
**作者**：Cabodi S, et al.
**摘要**：通过BCAR1抗体进行组织芯片分析，发现BCAR1在肿瘤相关成纤维细胞(CAFs)中高表达，并通过整合素信号促进细胞外基质重塑。研究强调了BCAR1抗体在肿瘤微环境研究中的诊断价值。
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3. **文献名称**：*BCAR1 Antibody-Based Proteomic Profiling in Triple-Negative Breast Cancer*
**作者**：Zhang Y, et al.
**摘要**：结合BCAR1抗体与质谱技术，系统分析了三阴性乳腺癌中BCAR1的互作蛋白网络，发现其与FAK和Crk的相互作用驱动侵袭性表型，为靶向治疗提供新方向。
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这些文献均以BCAR1抗体为核心实验工具，涵盖耐药机制、微环境调控及蛋白质组学分析等领域，可为基础研究与临床应用提供参考。
**Background of BCAR1 Antibody**
BCAR1 (Breast Cancer Anti-estrogen Resistance 1), also known as p130Cas, is a scaffold protein encoded by the *BCAR1* gene. It plays a critical role in cellular signaling pathways, particularly those regulating cell adhesion, migration, proliferation, and survival. BCAR1 interacts with integrins, growth factor receptors, and tyrosine kinases, facilitating signal transduction through its multi-domain structure, which includes a Src homology 3 (SH3) domain and multiple substrate-binding regions.
BCAR1 antibodies are essential tools for studying its expression, localization, and function in both normal and pathological contexts. These antibodies enable detection via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Research has highlighted BCAR1's involvement in cancer progression, especially in breast cancer, where its overexpression is linked to anti-estrogen therapy resistance. Elevated BCAR1 levels correlate with enhanced cell invasion, metastasis, and poor prognosis in various cancers, including prostate, lung, and ovarian malignancies.
Additionally, BCAR1 antibodies aid in exploring its role in physiological processes like embryonic development and immune responses. Recent studies focus on BCAR1's interaction with signaling molecules (e.g., FAK, Src) and its potential as a therapeutic target. By modulating pathways such as ERK/MAPK and PI3K/AKT, BCAR1 influences tumor cell adaptability, making it a biomarker of interest for personalized oncology strategies.
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