| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | H3 K9 HMTase 2; KMT1B; Su(var)3 9 homolog 2; Suv39h2;;KMT1B |
| WB Predicted band size | 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human KMT1B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇与KMT1B/SUV39H2抗体相关的参考文献及其摘要概括：
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1. **"Role of the SUV39H2 histone methyltransferase in heterochromatin formation"**
*Rea, S. et al. (2002). Nature*
- 研究SUV39H2在异染色质形成中的功能，通过特异性抗体验证其在哺乳动物细胞中催化H3K9三甲基化，并揭示其与HP1蛋白的相互作用。
2. **"SUV39H2 silencing enhances DNA damage sensitivity in cancer cells"**
*Liu, C. et al. (2015). Oncogene*
- 使用抗SUV39H2抗体进行Western blot和免疫荧光分析，发现其表达下调增加癌细胞对DNA损伤的敏感性，提示其作为癌症治疗靶点的潜力。
3. **"CRISPR-based screening identifies SUV39H2 as a regulator of viral latency"**
*Zhang, Y. et al. (2018). Cell Reports*
- 通过CRISPR筛选结合抗SUV39H2抗体验证，发现该酶通过修饰病毒基因组H3K9甲基化调控疱疹病毒潜伏感染。
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注：KMT1B为SUV39H2的别名，上述文献均涉及该蛋白抗体的实验应用(如检测表达、定位或功能研究)。如需更多文献或DOI号，可进一步补充检索条件。
The KMT1B/SUV39H2 antibody is a crucial tool for studying the SUV39H2 protein, a member of the SUV39 subfamily of histone methyltransferases (HMTs). SUV39H2. also known as KMT1B, catalyzes the trimethylation of histone H3 at lysine 9 (H3K9me3), a hallmark of transcriptionally repressive heterochromatin. This enzyme plays a pivotal role in epigenetic regulation, maintaining genomic stability, and silencing retrotransposons. It shares functional redundancy with its paralog SUV39H1 (KMT1A), though SUV39H2 exhibits distinct expression patterns, including higher activity in germ cells and during early development. Dysregulation of SUV39H2 has been implicated in cancer, aging, and developmental disorders due to its influence on chromatin structure and gene expression.
The antibody targeting SUV39H2 enables researchers to detect and quantify its expression, localization, and interaction partners in various experimental settings, such as Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP). Validated antibodies are essential for distinguishing SUV39H2 from related HMTs, given the high sequence homology within the SUV39 family. Specificity is often confirmed using knockout controls or siRNA knockdown. Studies employing this antibody have shed light on SUV39H2's role in X-chromosome inactivation, telomere maintenance, and cellular differentiation. Its application in disease models further highlights its potential as a therapeutic target or biomarker for conditions linked to epigenetic dysregulation.
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