| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PCTT; PSTI; SPINK1; Spink3; TaTI; TCP;;SPINK1 |
| WB Predicted band size | Calculated MW: 9 kDa ; Observed MW: 11 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human SPINK1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于SPINK1抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*"SPINK1 as a biomarker in pancreatic cancer: Immunohistochemical analysis"*
**作者**：Smith A, et al.
**摘要**：通过免疫组化技术，研究SPINK1蛋白在胰腺导管腺癌组织中的表达，发现其高表达与患者预后不良及肿瘤侵袭性相关，提示SPINK1可能作为潜在的诊断标志物。
2. **文献名称**：*"SPINK1 autoantibodies in chronic pancreatitis: Clinical relevance"*
**作者**：Lee B, et al.
**摘要**：探讨慢性胰腺炎患者血清中SPINK1自身抗体的存在及其意义，发现抗体阳性与疾病进展和胰腺功能损伤显著相关，为疾病分型提供依据。
3. **文献名称**：*"SPINK1 promotes prostate cancer metastasis via EGFR signaling"*
**作者**：Johnson C, et al.
**摘要**：结合Western blot和免疫荧光技术，揭示SPINK1通过激活EGFR信号通路促进前列腺癌细胞迁移和转移，为靶向治疗提供新方向。
4. **文献名称**：*"SPINK1 expression in breast cancer: Correlation with drug resistance"*
**作者**：Wang Y, et al.
**摘要**：利用免疫组化分析乳腺癌组织中SPINK1的表达水平，发现其高表达与化疗耐药性相关，提示抑制SPINK1可能增强传统化疗效果。
(注：以上文献信息为示例，实际引用需根据真实研究核实。)
The SPINK1 (Serine Peptidase Inhibitor Kazal Type 1) antibody is a tool used to detect and study the SPINK1 protein, a trypsin inhibitor primarily produced in the pancreas. SPINK1. also known as pancreatic secretory trypsin inhibitor (PSTI), plays a critical role in preventing premature activation of trypsinogen within pancreatic acinar cells, thereby protecting against autodigestion and tissue damage. Dysregulation of SPINK1 has been linked to pancreatic disorders, including chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC), where its overexpression is observed in tumor-associated stroma and neoplastic cells.
SPINK1 antibodies are widely utilized in research to investigate the protein's expression patterns, biological functions, and mechanisms in disease contexts. Immunohistochemistry (IHC), Western blotting, and ELISA are common applications, helping to correlate SPINK1 levels with pathological conditions. Additionally, these antibodies aid in studying SPINK1's role beyond the pancreas, such as in prostate, gastrointestinal, and liver cancers, where its aberrant expression may influence tumor progression or serve as a biomarker.
Genetic mutations in the SPINK1 gene (e.g., N34S variant) are associated with hereditary pancreatitis, making antibodies valuable for exploring genotype-phenotype relationships. Commercial SPINK1 antibodies are typically raised in rabbits or mice, targeting specific epitopes to ensure specificity. Their development continues to support both diagnostic potential and therapeutic targeting in SPINK1-related pathologies.
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