Rabbit Monoclonal TNNI1 Antibody

The TNNI1 antibody is a immunological tool designed to detect and quantify troponin I type 1 (TNNI1), a protein encoded by the TNNI1 gene in humans. TNNI1. also known as slow skeletal muscle troponin I, is a key component of the troponin complex that regulates calcium-dependent skeletal muscle contraction. It is predominantly expressed in slow-twitch (Type I) skeletal muscle fibers and plays a role in maintaining muscle tone and endurance. Research involving TNNI1 antibodies is critical for studying muscle development, function, and disorders such as congenital myopathies or muscular dystrophies. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to localize TNNI1 expression in tissues or assess its expression levels under pathological conditions. Notably, TNNI1 has also been investigated in certain cancers, including rhabdomyosarcoma, due to its muscle-specific expression. Commercially available TNNI1 antibodies are typically validated for specificity against human, mouse, or rat samples, with applications spanning basic research and diagnostic development. Its distinction from cardiac troponin I (TNNI3) makes it a valuable marker for differentiating skeletal muscle-specific pathologies from cardiac conditions in clinical settings.