| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | baz1b; hWALP2; WALP2; WBRS9; WBSC10; WBSCR10; WBSCR9; WSTF;;BAZ1B |
| WB Predicted band size | Calculated MW: 171 kDa ; Observed MW: 185 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human BAZ1B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于WSTF抗体的3篇参考文献示例(文献信息为虚构模拟，仅供参考格式)：
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1. **文献名称**：*WSTF interacts with ISWI chromatin remodeling complexes in transcriptional regulation*
**作者**：Xue Y. et al.
**摘要**：研究通过WSTF抗体的免疫共沉淀实验，揭示了WSTF蛋白与ISWI家族染色质重塑复合物的相互作用，调控靶基因表达及染色质结构重组。
2. **文献名称**：*WSTF phosphorylation of histone H2AX in DNA damage response*
**作者**：Kitagawa R. et al.
**摘要**：利用WSTF抗体进行染色质免疫沉淀(ChIP)分析，发现WSTF通过磷酸化H2AX调控DNA损伤修复通路，维持基因组稳定性。
3. **文献名称**：*BAZ1B/WSTF mediates replication stress tolerance via chromatin remodeling*
**作者**：Nakamura K. et al.
**摘要**：通过Western blot和免疫荧光技术(使用WSTF抗体)，证实BAZ1B/WSTF通过重塑复制叉处染色质结构，缓解复制应激引发的DNA损伤。
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(注：以上文献信息为示例，实际引用请核实真实数据库如PubMed或Google Scholar。)
The Williams syndrome transcription factor (WSTF), encoded by the *BAZ1B* gene, is a critical regulatory protein involved in chromatin remodeling and transcriptional modulation. It functions as a core component of the ISWI (imitation switch) family of ATP-dependent chromatin-remodeling complexes, notably the WICH complex (WSTF-ISWI chromatin-remodeling complex). WSTF interacts with nucleosomes through its WAC, DDT, and PHD domains, facilitating histone H2A lysine ubiquitination and promoting DNA repair, replication, and transcriptional regulation.
WSTF antibodies are widely used to study its role in chromatin dynamics, epigenetic inheritance, and disease pathogenesis. Research highlights its involvement in Williams syndrome, a neurodevelopmental disorder caused by a chromosomal deletion encompassing *BAZ1B*. Antibodies targeting WSTF enable detection via techniques like Western blotting, immunofluorescence, and ChIP-seq, aiding investigations into its interactions with histone variants (e.g., H2A.X) and other chromatin remodelers. Dysregulation of WSTF has also been implicated in cancer and immunodeficiency, underscoring its broader biomedical relevance. These tools are essential for dissecting mechanisms of genome stability and epigenetic regulation.
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