| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CENP-C; CENPC1; hcp-4; ICEN7; MIF2;;CENPC |
| WB Predicted band size | 107 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human CENPC |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于CENPC抗体的模拟参考文献示例(建议通过PubMed或Google Scholar检索真实文献)：
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1. **文献名称**：*Autoantibodies to centromere protein C in systemic sclerosis: clinical associations*
**作者**：Rothfield, N. et al.
**摘要**：研究系统性硬化症(硬皮病)患者中CENPC抗体的临床意义，发现其与局限型皮肤病变相关，且患者内脏器官(如肺、肾)受累风险较低。
2. **文献名称**：*CENPC-specific autoantibodies in primary biliary cirrhosis: a cohort study*
**作者**：Yang, L. et al.
**摘要**：分析原发性胆汁性胆管炎(PBC)患者中CENPC抗体的预后价值，表明抗体阳性患者疾病进展更缓慢，肝功能指标(如ALP)改善更显著。
3. **文献名称**：*Molecular characterization of CENPC and its role in centromere assembly*
**作者**：Sullivan, B.A. & Schwartz, S.
**摘要**：阐述CENPC蛋白在着丝粒结构和染色体分离中的关键作用，并探讨自身抗体可能通过干扰CENPC功能导致染色体不稳定性。
4. **文献名称**：*Comparative analysis of anti-centromere antibodies targeting CENP-A, CENP-B, and CENP-C in autoimmune diseases*
**作者**：Marion, T.N. et al.
**摘要**：比较不同抗着丝粒抗体的特异性，发现CENPC抗体在系统性硬化症中的阳性率显著高于其他自身免疫病，提示其作为疾病分型的潜在标志物。
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**备注**：以上为模拟示例，实际文献请通过学术数据库(如PubMed、Web of Science)检索关键词“CENPC antibody”“anti-centromere antibody CENP-C”或结合疾病名称(如“systemic sclerosis”“PBC”)获取最新研究。
The CENPC antibody targets centromere protein C (CENP-C), a critical component of the centromere, a specialized chromosomal region essential for proper chromosome segregation during cell division. CENP-C is part of the constitutive centromere-associated network (CCAN), which stabilizes kinetochore assembly and ensures accurate microtubule attachment. Structurally, it interacts with other centromere proteins like CENP-A and CENP-B, anchoring the kinetochore to chromatin.
In clinical contexts, anti-CENPC antibodies are primarily associated with autoimmune diseases, particularly systemic sclerosis (scleroderma) and the CREST syndrome (Calcinosis, Raynaud’s phenomenon, Esophageal dysmotility, Sclerodactyly, Telangiectasia). These autoantibodies are detected via indirect immunofluorescence (IIF) or ELISA, often alongside other anti-centromere antibodies (e.g., anti-CENPA, -B). Their presence is a diagnostic marker, correlating with limited cutaneous involvement and a lower risk of severe organ complications compared to other scleroderma subtypes. Anti-CENPC antibodies are also observed in a subset of systemic lupus erythematosus (SLE) or primary biliary cholangitis cases.
Research into CENPC’s role extends beyond autoimmunity. Mutations or dysregulation of CENP-C are linked to chromosomal instability, mitotic errors, and cancers. Studies using CENPC antibodies in molecular biology help elucidate centromere function, aiding advancements in understanding genomic integrity and diseases tied to cell division defects.
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