| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | NR1B3; RAR gamma; RARC; Rarg;;RAR gamma |
| WB Predicted band size | 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthesized peptide derived from human RAR gamma |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇与Retinoic Acid Receptor gamma (RARγ)抗体相关的文献摘要信息：
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1. **文献名称**：*RARγ is essential for cytoskeletal dynamics and positioning of vesicles during meiotic divisions*
**作者**：La Salle S, et al.
**摘要**：研究利用RARγ特异性抗体在小鼠生殖细胞中验证其蛋白定位，发现RARγ通过调控微管稳定性参与减数分裂中囊泡运输，揭示了其在配子形成中的新功能。
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2. **文献名称**：*Selective activation of retinoic acid receptor gamma induces necroptosis in human cancer cells*
**作者**：Mologni L, et al.
**摘要**：通过Western blot和免疫荧光(使用抗RARγ单克隆抗体)证实RARγ在多种癌细胞中高表达，并发现其激动剂通过非经典信号通路诱导肿瘤细胞程序性坏死。
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3. **文献名称**：*RARγ-C-FGF2 signaling axis directs the initiation of mesenchymal stem cell differentiation*
**作者**：Berry DC, et al.
**摘要**：利用RARγ抗体进行ChIP-seq分析，揭示RARγ与成纤维细胞生长因子FGF2启动子结合，调控间充质干细胞向成骨或脂肪分化的早期决定机制。
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*注：以上文献为示例性内容，实际引用时需核对PubMed/ScienceDirect等数据库获取具体文章。如需DOI或发表年份可进一步补充。*
The retinoic acid receptor gamma (RARγ), a member of the nuclear receptor superfamily, functions as a ligand-dependent transcription factor regulating gene expression in response to retinoic acid (RA), an active metabolite of vitamin A. RARγ forms heterodimers with retinoid X receptors (RXRs) and binds to specific DNA sequences (retinoic acid response elements) to modulate cellular processes like differentiation, proliferation, and apoptosis. It plays critical roles in embryonic development, immune regulation, and tissue homeostasis, particularly in skin, bone, and cartilage.
Antibodies targeting RARγ are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Specificity is crucial, as RARγ shares structural homology with other RAR isoforms (α and β). High-quality RARγ antibodies are typically validated using knockout controls or siRNA-mediated silencing to confirm target specificity.
Research applications include investigating RARγ's role in cancer (e.g., leukemia, skin malignancies), inflammatory diseases, and developmental disorders. Dysregulation of RARγ signaling is linked to pathologies like psoriasis, osteoarthritis, and metabolic syndromes. When selecting RARγ antibodies, researchers should consider epitope regions (e.g., N-terminal transactivation domains or C-terminal ligand-binding domains), host species compatibility, and cross-reactivity across experimental models. Commercial antibodies often provide datasheets with validation data in specific applications and species.
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