| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Casein;;alpha S1 casein |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human alpha S1 casein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于Casein抗体的代表性文献概览(信息基于模拟学术数据，非真实文献)：
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1. **文献名称**：*Casein-specific IgE and IgG antibodies in childhood milk allergy diagnosis*
**作者**：Smith A, et al.
**摘要**：研究探讨了血清中casein特异性IgE和IgG抗体对儿童牛奶过敏的诊断价值，发现IgE抗体与急性过敏反应显著相关，而IgG可能反映免疫耐受状态。
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2. **文献名称**：*Autoantibodies to casein in type 1 diabetes: epitope mapping and clinical relevance*
**作者**：Jones B, et al.
**摘要**：分析了1型糖尿病患者体内casein自身抗体的表位特征，提出牛奶摄入可能通过分子模拟机制触发针对胰岛β细胞的交叉免疫反应。
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3. **文献名称**：*Development of a high-sensitivity ELISA for detecting anti-casein IgA in celiac disease*
**作者**：Chen L, et al.
**摘要**：开发了一种新型ELISA方法，用于检测乳糜泻患者中casein特异性IgA抗体，证实其与肠道炎症程度呈正相关，提示casein可能加剧乳糜泻病理进程。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“casein antibody allergy/diabetes/celiac”获取近年研究。
Casein antibodies are immunoglobulins targeting caseins, a family of phosphoproteins that constitute the major protein component in mammalian milk (primarily α-, β-, and κ-caseins). These antibodies are of significant interest in both clinical and research contexts. In clinical settings, casein antibodies are commonly studied in relation to cow's milk allergy (CMA), a hypersensitivity reaction where the immune system mistakenly identifies caseins or other milk proteins as threats. Specific IgE antibodies against caseins are key biomarkers for diagnosing CMA, particularly in children.
In research, casein antibodies serve as tools to investigate milk protein metabolism, immune responses, and cross-reactivity with other proteins. They are also used in immunoassays (e.g., ELISA) to quantify casein content in food products, ensuring compliance with allergen-labeling regulations. Additionally, casein autoantibodies have been explored in autoimmune conditions like celiac disease, where molecular mimicry between dietary proteins and self-antigens may contribute to pathogenesis.
Polyclonal and monoclonal casein antibodies are commercially available, often derived from immunized animals (e.g., rabbits, mice). Their applications extend to immunohistochemistry, Western blotting, and studying casein's role in calcium phosphate stabilization in milk. Recent studies also examine casein hydrolysates and antibody responses in hypoallergenic infant formulas.
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