首页 / 产品 / 抗体 / 一抗

Rabbit Monoclonal RORbeta Antibody

  • 中文名: RORbeta抗体
  • 别    名: NR1F2; ROR BETA; Rorb; RZR BETA; RZRB;;Nuclear receptor ROR beta
货号: IPDX18217
Price: ¥1280
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesNR1F2; ROR BETA; Rorb; RZR BETA; RZRB;;Nuclear receptor ROR beta
WB Predicted band size53 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenA synthesized peptide derived from human Nuclear receptor ROR beta
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

+ +

参考文献

以下是关于RORβ抗体的3篇参考文献示例(注意:以下文献信息为模拟内容,实际文献请通过PubMed或Google Scholar检索):

1. **文献名称**: "RORβ antibody specificity validation in the developing mouse retina"

**作者**: Smith A, et al.

**摘要**: 本研究通过免疫组化和Western blot验证了RORβ抗体在小鼠视网膜发育中的特异性,发现其在光感受器细胞中高表达,并证实了抗体在不同实验模型中的可靠性。

2. **文献名称**: "Role of RORβ in circadian rhythm regulation: Insights from antibody-based knockout models"

**作者**: Lee JH, et al.

**摘要**: 利用RORβ特异性抗体分析基因敲除小鼠的脑组织,发现RORβ缺失导致昼夜节律相关基因(如Bmal1)表达异常,提示其在生物钟调控中的关键作用。

3. **文献名称**: "RORβ expression in human neurodegenerative diseases: A comparative immunohistochemical study"

**作者**: Garcia R, et al.

**摘要**: 使用RORβ抗体对阿尔茨海默病和帕金森病患者脑组织进行免疫染色,发现其表达水平与神经元存活率相关,为神经退行性疾病的机制研究提供新线索。

如需具体文献,建议通过关键词“RORβ antibody”或“RORB immunohistochemistry”在学术数据库中检索最新研究。

背景信息

The retinoid-related orphan receptor beta (RORβ), a member of the nuclear receptor superfamily, functions as a ligand-dependent transcription factor regulating gene expression involved in circadian rhythm, neural development, and photoreceptor differentiation. Primarily expressed in the retina, brain, and pineal gland, RORβ plays critical roles in maintaining retinal circuitry, dopaminergic signaling, and circadian clock machinery. Antibodies targeting RORβ are essential tools for investigating its expression patterns, molecular interactions, and pathological implications. These antibodies are commonly validated for applications like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP), with specificity often confirmed using RORβ-knockout cell lines or tissues.

Research utilizing RORβ antibodies has revealed its association with neurological disorders (e.g., autism spectrum disorders), retinal degeneration, and cancer progression. For example, studies demonstrate RORβ's dual role as a tumor suppressor or promoter in different cancers, depending on cellular context. Challenges in antibody development include distinguishing between RORβ isoforms (RORβ1 and RORβ2) and minimizing cross-reactivity with homologous receptors (RORα/RORγ). High-quality RORβ antibodies remain crucial for advancing therapeutic strategies, such as designing RORβ-targeted drugs for circadian-related diseases or neurodegeneration. Recent efforts also focus on mapping RORβ's genomic targets through ChIP-seq to elucidate its regulatory networks in health and disease.

客户数据及评论

折叠内容

大包装询价

×