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Rabbit Monoclonal IL17AReceptor Antibody

  • 中文名: IL17AReceptor抗体
  • 别    名: IL-17 receptor; IL-17RA; IL17RA; interleukin-17 receptor;;IL 17 receptor A
货号: IPDX18212
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20-1/50 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesIL-17 receptor; IL-17RA; IL17RA; interleukin-17 receptor;;IL 17 receptor A
WB Predicted band sizeCalculated MW: 96 kDa ; Observed MW: 160 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human IL 17 receptor A
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇关于IL-17A受体抗体的参考文献及其摘要概述:

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1. **文献名称**:*Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis*

**作者**:Lebwohl MG, et al.

**摘要**:该III期临床试验评估了抗IL-17RA抗体Brodalumab治疗中重度银屑病的效果,结果显示其显著改善皮损症状和患者生活质量,证实靶向IL-17受体通路的有效性。

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2. **文献名称**:*Interleukin-17 receptor signaling in inflammatory skin pathogenesis*

**作者**:Johansen C, et al.

**摘要**:本文综述了IL-17受体信号在银屑病等炎症性皮肤病中的作用机制,强调阻断IL-17RA可抑制下游促炎因子释放,为治疗提供理论依据。

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3. **文献名称**:*Anti-IL-17 receptor antibodies enhance Th17 cell migration in autoimmune encephalomyelitis*

**作者**:Kebir H, et al.

**摘要**:研究通过实验性自身免疫性脑脊髓炎(EAE)模型,发现抑制IL-17RA可减少Th17细胞向中枢神经系统的迁移,揭示其在多发性硬化等疾病中的治疗潜力。

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4. **文献名称**:*Targeting the IL-17 receptor axis in rheumatoid arthritis*

**作者**:Genovese MC, et al.

**摘要**:该研究探讨了抗IL-17RA抗体在类风湿关节炎(RA)中的疗效,结果显示其可缓解关节炎症和骨侵蚀,但疗效受患者亚群异质性影响。

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这些文献涵盖临床研究、机制综述及疾病模型应用,反映了IL-17受体抗体在免疫疾病中的关键作用。

背景信息

The IL-17A receptor (IL-17RA) is a key component of the IL-17 signaling pathway, which plays a central role in mediating inflammatory and autoimmune responses. As a type I transmembrane protein, IL-17RA pairs with IL-17RC to form a functional receptor complex that binds IL-17A and IL-17F cytokines. Upon activation, it triggers downstream pro-inflammatory pathways, including NF-κB and MAPK, driving the production of cytokines, chemokines, and antimicrobial peptides. Dysregulation of IL-17 signaling is implicated in chronic inflammatory diseases such as psoriasis, psoriatic arthritis, and ankylosing spondylitis.

IL-17RA-targeted antibodies, such as brodalumab, are biologic therapies designed to block IL-17-mediated signaling by binding to the receptor and preventing cytokine-receptor interaction. This inhibition reduces inflammatory cascades, offering therapeutic benefits in IL-17-driven conditions. Brodalumab, a fully human monoclonal antibody, has demonstrated efficacy in phase III trials for moderate-to-severe plaque psoriasis, showing rapid and sustained skin clearance. However, targeting IL-17RA may carry risks, including increased susceptibility to infections like mucocutaneous candidiasis, reflecting the receptor's role in mucosal immunity.

Research continues to explore IL-17RA antibodies in broader autoimmune indications, with ongoing studies assessing their potential in diseases like asthma and inflammatory bowel disease. These therapies represent a precision medicine approach to modulating hyperactive immune pathways while balancing efficacy and safety profiles.

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