| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Stk33;;STK33 |
| WB Predicted band size | Calculated MW: 58 kDa ; Observed MW: 58,50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human STK33 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇与STK33抗体相关的文献摘要概括(注：文献为示例性质，实际引用需核实)：
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1. **标题**: *STK33 interacts with NF-κB signaling in pancreatic cancer progression*
**作者**: Müller, A., et al.
**摘要**: 研究利用STK33特异性抗体进行免疫沉淀，发现STK33与NF-κB通路蛋白相互作用，促进胰腺癌细胞存活和化疗耐药，提示其作为治疗靶点的潜力。
2. **标题**: *STK33 as a biomarker in colorectal cancer: Immunohistochemical analysis*
**作者**: Chen, L., & Wang, Y.
**摘要**: 通过开发高特异性STK33单克隆抗体，对结直肠癌组织进行免疫组化分析，发现STK33高表达与患者预后不良显著相关，可能成为诊断标志物。
3. **标题**: *Functional characterization of STK33 kinase activity in neuronal development*
**作者**: Gupta, R., et al.
**摘要**: 研究采用STK33抗体进行Western blot和免疫荧光，证实STK33通过调控MAPK通路影响神经元突触形成，揭示其在神经发育中的新功能。
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**注**：以上文献信息为模拟生成，实际引用需通过PubMed、Web of Science等数据库检索真实文献。建议使用关键词“STK33 antibody”或“STK33 kinase”结合“biomarker/therapeutic target”等进一步筛选。
The serine/threonine kinase 33 (STK33) is a protein kinase belonging to the calcium/calmodulin-dependent kinase superfamily. It is encoded by the *STK33* gene and is implicated in diverse cellular processes, including cell cycle regulation, DNA damage response, and apoptosis. Structurally, STK33 contains a conserved kinase domain with ATP-binding motifs, enabling phosphorylation-dependent signaling. While its precise biological roles remain under investigation, studies suggest its involvement in tumorigenesis, particularly in cancers with KRAS mutations, where STK33 may act as a survival factor for proliferating cells. However, conflicting reports on its oncogenic relevance highlight the need for further research.
STK33-specific antibodies are critical tools for detecting and quantifying STK33 protein expression in research settings. These antibodies are used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study STK33 localization, expression levels, and interactions in cellular or tissue samples. Validated antibodies help clarify STK33's role in disease mechanisms, such as cancer progression or response to genotoxic stress. Commercial STK33 antibodies are typically raised against epitopes within its kinase domain or C-terminal regions, with specificity confirmed via knockout controls.
Despite its potential as a therapeutic target, STK33's functional complexity and context-dependent activity pose challenges. Reliable antibodies remain essential for unraveling its signaling networks and evaluating its candidacy for targeted therapies. Ongoing research aims to reconcile discrepancies in STK33's role across cancer types and explore its interplay with other oncogenic pathways.
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