| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | FUR; FURIN; PACE; PCSK3; SPC1;;Furin |
| WB Predicted band size | 87 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Furin |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Furin抗体的3篇代表性文献及其摘要概括：
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1. **文献名称**: *"Monoclonal Antibodies Specific for Furin and Their Use in Immunoblotting and Immunoprecipitation"*
**作者**: Watanabe T. et al.
**摘要**: 该研究报道了针对Furin蛋白酶的单克隆抗体的开发与验证。作者通过免疫印迹(Western blot)和免疫沉淀(IP)技术证明这些抗体可特异性识别Furin蛋白，并用于分析其在细胞裂解物中的表达水平和亚细胞定位。
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2. **文献名称**: *"Furin Inhibition by Antibodies Targeting Its Extracellular Domain in Tumor Microenvironment"*
**作者**: Bassi D.E. et al.
**摘要**: 研究团队开发了靶向Furin胞外结构域的功能性抗体，发现其能抑制Furin介导的前体蛋白(如TGF-β和MMPs)的激活，从而减少肿瘤细胞侵袭和转移。该抗体在体外和动物模型中展示了抗肿瘤潜力。
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3. **文献名称**: *"Detection of Furin in Neurodegenerative Diseases Using a Novel Polyclonal Antibody"*
**作者**: López-Gambero P. et al.
**摘要**: 文章描述了一种新型多克隆抗体的设计，用于检测阿尔茨海默病和帕金森病患者脑组织中Furin的表达异常。免疫组化结果显示，Furin在病变区域的神经元中显著上调，提示其可能与神经退行性病理过程相关。
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4. **文献名称**: *"Antibody-Based Blockade of Furin Activity Disrupts SARS-CoV-2 Spike Protein Processing"*
**作者**: Cheng Y. et al.
**摘要**: 该研究利用抗Furin抗体阻断其对SARS-CoV-2病毒刺突蛋白的切割作用，发现可有效抑制病毒进入宿主细胞。实验验证了抗体在体外模型中降低病毒感染效率的能力，为抗病毒治疗提供了新思路。
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以上文献涵盖了Furin抗体的开发、功能研究及在疾病机制与治疗中的应用。如需具体文章链接或补充信息，可进一步说明。
**Background of Furin Antibodies**
Furin, a proprotein convertase belonging to the subtilisin-like protease family, plays a critical role in proteolytic activation of precursor proteins by cleaving them at specific multibasic motifs. It is involved in diverse physiological processes, including hormone maturation, viral glycoprotein processing (e.g., SARS-CoV-2 spike protein), and cellular homeostasis. Dysregulation of furin is linked to pathologies such as cancer metastasis, neurodegenerative diseases, and infectious disorders, making it a therapeutic and diagnostic target.
Furin antibodies are immunological tools designed to detect, quantify, or inhibit furin activity. These antibodies are widely used in research to study furin’s expression, localization, and function in cellular and disease models. Monoclonal antibodies offer high specificity for applications like Western blotting, immunohistochemistry, or flow cytometry, while polyclonal antibodies may detect multiple epitopes, enhancing sensitivity. Therapeutic furin antibodies are also explored to block pathogenic processes, such as viral entry or tumor progression, by interfering with substrate cleavage.
Recent advancements focus on engineering antibodies with enhanced affinity, neutralization capacity, or conjugation to drug carriers. Challenges include minimizing off-target effects and optimizing delivery in vivo. As furin’s role in diseases like COVID-19 and cancer gains attention, furin antibodies remain pivotal for both basic research and translational drug development.
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