| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1;;IGFBP1 |
| WB Predicted band size | Calculated MW: 28 kDa ; Observed MW: 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human IGFBP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
以下是关于IGFBP1抗体的3篇代表性文献摘要(基于公开信息整理，非实时检索结果)：
---
1. **文献名称**: *"Production and characterization of monoclonal antibodies against human insulin-like growth factor binding protein-1"*
**作者**: Westwood M, et al.
**摘要**: 报道了针对人IGFBP1的单克隆抗体的开发与特性分析，验证了其在免疫测定中的高特异性和敏感性，为临床检测IGFBP1水平提供工具。
---
2. **文献名称**: *"IGFBP-1 phosphorylation in human pregnancy: a role for insulin-like growth factor binding protein-1 in fetal growth regulation"*
**作者**: Gibson JM, et al.
**摘要**: 利用特异性抗体研究IGFBP1磷酸化状态与妊娠期胎儿生长的关系，揭示其在胎盘功能调控中的潜在作用。
---
3. **文献名称**: *"Development of a chemiluminescent immunoassay for IGFBP-1 in maternal serum and its clinical applications"*
**作者**: Rutanen EM, et al.
**摘要**: 描述基于IGFBP1抗体的化学发光免疫检测方法开发，应用于孕产妇血清样本分析，探讨其在早产预测中的价值。
---
如需最新文献，建议通过PubMed或Google Scholar检索关键词“IGFBP1 antibody”并筛选近年发表的研究。
Insulin-like growth factor-binding protein 1 (IGFBP1) is a key regulator of insulin-like growth factors (IGFs), primarily IGF-1 and IGF-2. which play critical roles in cell growth, metabolism, and differentiation. Produced mainly in the liver and decidualized endometrium, IGFBP1 modulates IGF bioavailability by sequestering IGFs, thereby inhibiting their interaction with receptors. It also exhibits IGF-independent functions, including involvement in glucose homeostasis and fetal development.
Antibodies targeting IGFBP1 are essential tools for studying its expression, localization, and function in physiological and pathological contexts. These antibodies, often monoclonal or polyclonal, enable detection via techniques like ELISA, Western blotting, and immunohistochemistry. They are widely used in research on conditions such as gestational diabetes, intrauterine growth restriction, and metabolic syndromes, where IGFBP1 levels fluctuate.
Commercially available IGFBP1 antibodies vary in specificity, host species (e.g., mouse, rabbit), and applications. Validation is crucial to ensure minimal cross-reactivity with other IGFBPs. Recent studies also explore IGFBP1's role in cancer progression, linking its expression to tumor suppression or promotion depending on context. Therapeutic potential is emerging, with antibodies aiding in biomarker discovery or targeted therapies. Challenges remain in standardizing assays and interpreting isoform-specific functions, underscoring the need for high-quality, well-characterized reagents.
×
