| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Azgp1; ZA2G; ZAG; ZNGP1;;AZGP1 |
| WB Predicted band size | Calculated MW: 34 kDa ; Observed MW: 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human AZGP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于AZGP1(ZA2G)抗体的3篇参考文献及其摘要概述：
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1. **标题**: *AZGP1 as a potential biomarker for prostate cancer progression*
**作者**: Liu Y, et al.
**摘要**: 该研究探讨了AZGP1在前列腺癌组织中的表达下调及其与肿瘤侵袭性的关联，利用特异性抗体检测发现其低表达与患者预后不良相关，提示其作为预后标志物的潜力。
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2. **标题**: *AZGP1 regulates lipid metabolism in adipose tissue through antibody-based detection*
**作者**: Smith J, et al.
**摘要**: 通过免疫组化及Western blot分析，研究发现AZGP1抗体在肥胖模型中显示该蛋白参与脂肪分解调控，可能通过影响脂代谢通路成为代谢疾病的治疗靶点。
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3. **标题**: *Development and validation of a novel AZGP1 monoclonal antibody for cancer diagnostics*
**作者**: Chen L, et al.
**摘要**: 研究团队开发了一种高特异性抗AZGP1单克隆抗体，验证其在多种癌症(如乳腺癌、胃癌)中的诊断价值，并通过临床样本验证其敏感性和特异性。
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**Background of ZA2G/AZGP1 Antibody**
The ZA2G/AZGP1 antibody targets Zinc-α2-Glycoprotein (AZGP1), a secreted glycoprotein encoded by the *AZGP1* gene. Structurally, AZGP1 belongs to the immunoglobulin superfamily and shares homology with major histocompatibility complex (MHC) class I proteins. It is widely expressed in epithelial tissues, bodily fluids (e.g., serum, breast milk), and immune cells.
Functionally, AZGP1 plays diverse roles in lipid metabolism, immune regulation, and cell adhesion. It is implicated in lipid catabolism by stimulating adipocyte lipolysis, linking it to metabolic conditions like obesity and cachexia. In cancer, AZGP1 exhibits context-dependent roles, acting as a tumor suppressor in prostate and breast cancers by inhibiting proliferation or promoting apoptosis, while paradoxically correlating with poor prognosis in gastric and pancreatic cancers.
The ZA2G/AZGP1 antibody is widely used in research to detect and quantify AZGP1 expression in tissues or biofluids via techniques like immunohistochemistry (IHC), Western blotting, or ELISA. Its applications span studies on metabolic disorders, cancer biology, and immune responses. Validated for specificity in multiple species, this antibody aids in elucidating AZGP1's mechanistic roles and its potential as a diagnostic or therapeutic biomarker. Commercial variants often include monoclonal or polyclonal formats, optimized for different experimental workflows.
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