| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HTRP1; Mtrp1; TRP1; TRPC1; Trrp1;;TRPC1 |
| WB Predicted band size | Calculated MW: 91 kDa ; Observed MW: 120 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human TRPC1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于TRPC1抗体的3篇参考文献的简要总结：
1. **文献名称**: "TRPC1 channels mediate Ca²⁺ entry and regulate the proliferation of human cardiac fibroblast"
**作者**: G. Xu et al.
**摘要**: 该研究通过Western blot和免疫荧光技术使用TRPC1抗体，发现TRPC1在人心肌成纤维细胞中调控钙内流，并影响细胞增殖，提示其在心脏纤维化中的作用。
2. **文献名称**: "TRPC1 is essential for in vivo angiogenesis in endothelial cells"
**作者**: A. Kumar et al.
**摘要**: 作者利用TRPC1抗体进行免疫组化分析，证明TRPC1通过调节内皮细胞钙信号促进血管生成，敲除TRPC1会显著抑制小鼠模型中的血管形成。
3. **文献名称**: "Role of TRPC1 in neuronal apoptosis induced by oxidative stress"
**作者**: L. Chen et al.
**摘要**: 该研究使用TRPC1特异性抗体进行蛋白表达检测，发现TRPC1在氧化应激诱导的神经元凋亡中起关键作用，抑制TRPC1可减少钙超载和细胞死亡。
4. **文献名称**: "TRPC1 modulates the store-operated calcium entry in skeletal muscle cells"
**作者**: M. Vandebrouck et al.
**摘要**: 通过免疫沉淀和Western blot结合TRPC1抗体，研究发现TRPC1参与骨骼肌细胞中钙池操纵的钙内流(SOCE)，影响肌肉收缩和疾病相关机制。
以上研究均直接使用TRPC1抗体验证蛋白表达或定位，涉及心血管、神经及肌肉系统的功能机制分析。
TRPC1 (Transient Receptor Potential Canonical 1) is a member of the TRP channel superfamily, which plays a critical role in calcium signaling and cellular homeostasis. TRPC1 forms non-selective cation channels, often functioning as homomers or heteromers with other TRPC subunits, and is implicated in regulating store-operated calcium entry (SOCE), mechanosensation, and cell proliferation. Its expression is widespread, including in the brain, cardiovascular system, and epithelial tissues, linking it to diverse physiological and pathological processes such as neuronal development, cardiac hypertrophy, and cancer progression.
TRPC1-specific antibodies are essential tools for studying the protein's expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to validate TRPC1 in tissue samples, cultured cells, or disease models. Research utilizing these antibodies has revealed TRPC1's involvement in neurodegenerative diseases (e.g., Alzheimer's), cardiovascular disorders, and tumorigenesis, where dysregulated calcium signaling contributes to pathology. Some studies also explore TRPC1 as a potential therapeutic target or biomarker. However, antibody specificity remains a challenge due to homology among TRP subunits, necessitating careful validation via knockout controls or siRNA-based approaches. Commercial TRPC1 antibodies are typically raised against conserved epitopes in human, mouse, or rat sequences, enabling cross-species applications in translational research.
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