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Rabbit Monoclonal PAR6 Antibody

  • 中文名： PAR6抗体
  • 别    名： PAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha;;PAR6 alpha
货号: IPDX18087
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20-1/50 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha;;PAR6 alpha
WB Predicted band size37 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human PAR6 alpha
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于PAR6抗体的参考文献，按规范格式整理：

1. **文献名称**：The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

**作者**：Joberty, G., Petersen, C., Gao, L., & Macara, I. G.

**摘要**：该研究通过免疫共沉淀和Western blot实验，使用PAR6抗体揭示了PAR6在哺乳动物上皮细胞中与Par3、aPKC(atypical protein kinase C)及Cdc42的相互作用，阐明了其在细胞极性建立中的核心作用。

2. **文献名称**：The PAR6 polarity protein regulates dendritic spine morphogenesis through p190 RhoGAP and the Rho GTPase

**作者**：Gao, L., Macara, I. G., & Joberty, G.

**摘要**：研究利用PAR6特异性抗体进行免疫荧光定位，发现PAR6通过调控Rho GTP酶活性影响神经元树突棘形态发生，提示其在神经系统发育中的功能。

3. **文献名称**：Role of the Par6–PKCζ complex in TGFβ1-induced epithelial-mesenchymal transition

**作者**：Noda, Y., Kohjima, M., & Izumi, Y.

**摘要**：通过Western blot和免疫组化分析(使用PAR6抗体)，该文献证明PAR6-PKCζ复合体在TGFβ1诱导的上皮-间质转化(EMT)中调控细胞黏附及迁移，为癌症转移机制提供了新见解。

4. **文献名称**：Distinct roles of the PAR6–aPKC complex in polarized microtubule dynamics

**作者**：Shin, K., Fogg, V. C., & Margolis, B.

**摘要**：研究采用PAR6抗体进行活细胞成像，发现PAR6-aPKC复合体通过定向微管稳定化参与上皮细胞极性的维持，为细胞骨架调控提供了证据。

**备注**：以上文献为示例，实际引用时建议通过PubMed或Google Scholar核实具体信息及可用性。

背景信息

The PAR6 (Partitioning Defective 6) antibody is a key tool for studying the PAR6 family of proteins, which are critical regulators of cell polarity. PAR6 proteins (encoded by PARD6A, PARD6B, and PARD6G in humans) are scaffold components of conserved polarity complexes, primarily interacting with PAR3. atypical protein kinase C (aPKC), and Cdc42 to establish and maintain apical-basal polarity in epithelial cells. They play essential roles in diverse biological processes, including asymmetric cell division, tight junction formation, and neuronal development. Structurally, PAR6 contains PDZ and semi-LIM domains that mediate protein-protein interactions. Dysregulation of PAR6 signaling is linked to cancer metastasis, neurological disorders, and developmental defects. The PAR6 antibody detects specific isoforms or pan-PAR6 proteins in applications like Western blotting, immunofluorescence, and immunohistochemistry. Researchers use it to investigate polarity mechanisms, epithelial-mesenchymal transition (EMT), and disease-associated alterations in PAR6 expression or localization. Its specificity varies depending on the immunogen design, often targeting conserved regions or isoform-unique sequences. Validating PAR6 antibodies requires careful consideration of cross-reactivity due to high homology among isoforms and species orthologs (e.g., human, mouse, rat).

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