| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cecr5;;HDHD5 |
| WB Predicted band size | 46 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human HDHD5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于CECR5抗体的3篇参考文献的简要总结(注：CECR5相关研究较少，以下为模拟示例)：
1. **标题**: *CECR5 modulates immune response via adenosine deaminase regulation*
**作者**: Li, X. et al.
**摘要**: 研究利用CECR5抗体进行免疫共沉淀，发现CECR5与ADA2酶活性相关，可能通过调控T细胞分化影响自身免疫疾病进程。
2. **标题**: *CECR5 antibody-based biomarker screening in vascular inflammation*
**作者**: Martinez, R. & Kumar, S.
**摘要**: 开发高特异性CECR5单克隆抗体，证实其在动脉炎患者血清中高表达，提示其作为血管炎诊断标志物的潜力。
3. **标题**: *Structural characterization of CECR5 using cryo-EM and antibody mapping*
**作者**: Chen, H. et al.
**摘要**: 通过冷冻电镜结合CECR5抗体表位分析，解析了CECR5蛋白的三维结构，揭示其与染色质重塑复合物的相互作用界面。
注：CECR5研究尚处早期，实际文献可能较少。建议通过PubMed/Google Scholar以["CECR5" AND "antibody"]为关键词检索最新进展。若需具体文献协助，可提供更详细的研究方向。
**Background of CECR5 Antibody**
The CECR5 antibody targets the protein encoded by the *CECR5* gene (Cat Eye Syndrome Chromosome Region Candidate 5), also known as *ADA2* (Adenosine Deaminase 2). This gene, located on chromosome 22. encodes ADA2. a secreted enzyme involved in adenosine metabolism and immune regulation. Unlike the intracellular ADA1. ADA2 is predominantly expressed in myeloid cells and endothelial cells, playing roles in angiogenesis, inflammation, and maintaining vascular integrity.
Mutations in *CECR5/ADA2* are linked to ADA2 deficiency (DADA2), a rare autosomal recessive disorder characterized by vasculopathy, immune dysregulation, and stroke susceptibility. CECR5 antibodies are critical tools for studying ADA2 expression, function, and its pathological role in DADA2 and related conditions like systemic vasculitis or autoimmune disorders.
In research, CECR5 antibodies are used in techniques such as Western blotting, immunohistochemistry, and ELISA to quantify ADA2 levels in tissues or serum, aiding in disease diagnosis and mechanistic studies. They also support drug development by evaluating ADA2-targeted therapies or biomarkers. Recent studies explore ADA2's involvement in tumor microenvironments and metabolic diseases, broadening its clinical relevance. Overall, CECR5 antibodies are vital for advancing understanding of ADA2 biology and its therapeutic potential.
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