| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GTF2S; TCEA; Tcea1; TF2S; TFIIS;;TCEA1 |
| WB Predicted band size | 34 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human TCEA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
以下是3篇涉及TCEA1抗体的文献示例(文献名为虚构，供参考格式)：
---
1. **文献名称**: *TCEA1 as a novel biomarker in lung adenocarcinoma progression*
**作者**: Li, X. et al.
**摘要**: 研究利用TCEA1抗体通过免疫组化分析肺癌组织，发现TCEA1高表达与患者预后不良相关，提示其可能作为治疗靶点。
2. **文献名称**: *Functional characterization of TCEA1 in transcription elongation*
**作者**: Smith, J. & Brown, K.
**摘要**: 通过Western blot和ChIP实验验证TCEA1抗体特异性，证明TCEA1在RNA聚合酶II介导的转录延伸中起关键调控作用。
3. **文献名称**: *Development of a monoclonal antibody against human TCEA1 for diagnostic applications*
**作者**: Wang, Y. et al.
**摘要**: 报道了一种高特异性抗人TCEA1单克隆抗体的开发，并成功应用于ELISA和免疫荧光检测，为癌症早期诊断提供新工具。
---
注：以上文献信息为示例，实际研究中建议通过PubMed或Google Scholar以关键词“TCEA1 antibody”或“Transcription Elongation Factor A1”检索真实文献。
The TCEA1 (Transcription Elongation Factor A1) antibody is a tool used to study the TCEA1 protein, a critical component of the transcription elongation process in eukaryotic cells. TCEA1. also known as TFIIS, plays a key role in RNA polymerase II-mediated mRNA synthesis by resolving transcriptional pauses or arrests, ensuring efficient elongation. Structurally, it contains an N-terminal domain involved in RNA polymerase II binding and a C-terminal domain that stimulates transcript cleavage during stalling, aiding in the restart of transcription. Dysregulation of TCEA1 has been linked to various cancers, including cervical carcinoma and neuroblastoma, where its overexpression may promote tumor progression by enhancing oncogene transcription.
The TCEA1 antibody is widely utilized in molecular biology research to detect and quantify TCEA1 expression in tissues or cell lines via techniques like Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). It also aids in studying TCEA1’s interaction with other transcription factors, such as p53. and its role in DNA damage response pathways. Commercially available TCEA1 antibodies are typically validated for specificity and sensitivity, with applications in cancer research, transcriptional regulation studies, and investigations into cellular stress responses. Recent studies also explore its potential as a biomarker for therapeutic targeting in malignancies.
×
