| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DAZ associated protein 1; Dazap1;;DAZ associated protein 1 |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human DAZ associated protein 1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于DAZAP1抗体的代表性文献(示例性内容，建议根据实际研究核实)：
1. **文献名称**: *DAZAP1 modulates splicing and transcriptional activity in neurodevelopment*
**作者**: Zhang Y, et al.
**摘要**: 本研究利用DAZAP1特异性抗体，通过免疫荧光和Western blot技术，揭示了DAZAP1在小鼠大脑皮层神经元中的亚细胞定位，并发现其通过调控RNA剪接参与神经突触形成。
2. **文献名称**: *DAZAP1 acts as a tumor suppressor in colorectal cancer by regulating β-catenin signaling*
**作者**: Wang L, et al.
**摘要**: 作者通过DAZAP1抗体进行免疫组化分析，发现DAZAP1在结直肠癌组织中表达下调，并证明其缺失通过激活Wnt/β-catenin通路促进肿瘤侵袭。
3. **文献名称**: *DAZAP1 interacts with PABPC1 to mediate mRNA translational control*
**作者**: Chen X, et al.
**摘要**: 该研究利用DAZAP1抗体进行免疫共沉淀(Co-IP)实验，发现DAZAP1与多聚腺苷酸结合蛋白PABPC1相互作用，共同调控靶mRNA的翻译效率。
**提示**：以上文献信息为示例，实际文献需通过PubMed或Google Scholar以“DAZAP1 antibody”为关键词检索，并筛选涉及抗体具体应用的论文(如检测、定位或功能研究)。
The DAZAP1 (Deleted in Azoospermia Associated Protein 1) antibody is a tool used to study the DAZAP1 protein, a ubiquitously expressed RNA-binding protein implicated in mRNA metabolism, including splicing, transport, and translation. DAZAP1 contains two RNA recognition motifs (RRMs) and interacts with various proteins, such as members of the DAZ (Deleted in Azoospermia) family, which are critical for germ cell development. It plays roles in cellular processes like cell proliferation, differentiation, and stress response, with dysregulation linked to cancers, neurodevelopmental disorders, and infertility.
DAZAP1 antibodies, typically generated in rabbits or mice using immunogenic peptide sequences or recombinant protein fragments, enable detection of DAZAP1 in techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help elucidate DAZAP1's expression patterns, subcellular localization (nucleus and cytoplasm), and interactions in normal and diseased tissues. Research using DAZAP1 antibodies has revealed its tumor-suppressive or oncogenic roles in context-dependent malignancies and its involvement in neural development. Such studies underscore its potential as a biomarker or therapeutic target. Validation steps, including knockout controls, ensure antibody specificity for reliable experimental outcomes.
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