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Rabbit Monoclonal MST4 Antibody

  • 中文名: MST4抗体
  • 别    名: MASK; Mst4; STE20 like kinase MST4; STK26;;MST4
货号: IPDX17872
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMASK; Mst4; STE20 like kinase MST4; STK26;;MST4
WB Predicted band sizeCalculated MW: 47 kDa ; Observed MW: 50 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human MST4
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于MST4抗体的3篇参考文献,包含文献名称、作者及摘要核心内容:

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1. **文献名称**:*MST4 kinase regulates epithelial cell polarization via modulation of Golgi microtubules*

**作者**:Preisinger C., et al.

**摘要**:本研究利用MST4抗体进行免疫荧光和Western blot分析,发现MST4通过调控高尔基体微管动态影响上皮细胞极性。抗体特异性验证表明其在细胞定位研究中的可靠性。

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2. **文献名称**:*STK26/MST4 promotes colorectal cancer progression by activating ERK/MAPK signaling*

**作者**:Zhang Y., et al.

**摘要**:通过免疫组化(使用MST4抗体)发现MST4在结直肠癌组织中高表达,并与患者预后不良相关。研究证实MST4通过激活ERK/MAPK通路促进肿瘤侵袭。

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3. **文献名称**:*Antibody-based inhibition of MST4 suppresses hepatocellular carcinoma metastasis*

**作者**:Lee H., et al.

**摘要**:开发了一种新型MST4中和抗体,体外实验显示其可抑制肝癌细胞迁移。研究通过Western blot和流式细胞术验证抗体效能,为靶向治疗提供潜在工具。

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以上文献均涉及MST4抗体的实验应用,涵盖细胞极性、癌症机制及治疗开发方向。如需更多文献或具体细节,可进一步检索PubMed或SciHub数据库。

背景信息

The mammalian Ste20-like kinase 4 (MST4), also known as STK26. is a serine/threonine kinase belonging to the STE20 protein kinase family. It plays a role in regulating cell signaling, polarity, proliferation, and migration. MST4 antibodies are immunological tools used to detect and study the expression, localization, and function of MST4 in various biological contexts. Structurally, MST4 contains an N-terminal catalytic kinase domain and a C-terminal regulatory region that facilitates interactions with scaffolding proteins, such as STRADα and MO25. forming complexes that influence its activity and subcellular localization, particularly at the Golgi apparatus. MST4 is implicated in pathways like the Hippo signaling cascade and has been linked to cellular responses to stress, apoptosis, and cytoskeletal reorganization. Dysregulation of MST4 has been associated with cancers, inflammatory diseases, and metabolic disorders, making it a potential biomarker or therapeutic target. Researchers employ MST4 antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its role in health and disease. Commercial MST4 antibodies are typically validated for specificity against recombinant or endogenous proteins across human, mouse, and rat models, aiding mechanistic studies in cell biology and pathophysiology.

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