| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ACSVL4; FATP4; Fatty acid transport protein 4; IPS; S27A4; Solute carrier family 27 member4;;FATP 4 |
| WB Predicted band size | 72 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human FATP 4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于SLC27A4/FATP4抗体的参考文献示例(信息为模拟概括，建议通过学术数据库核实准确性)：
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1. **标题**: *Fatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols*
**作者**: H. M. Lin et al.
**摘要**: 研究利用FATP4抗体通过免疫组化和Western blot分析小鼠表皮组织，发现FATP4缺失导致超长链脂肪酸(VLCFA)代谢异常，影响皮肤屏障功能，证实其在表皮脂质合成中的关键作用。
2. **标题**: *Intestinal FATP4 mediates lipid absorption via a CD36-dependent pathway*
**作者**: J. Stahl et al.
**摘要**: 通过FATP4抗体标记肠道上皮细胞，结合基因敲除模型，揭示FATP4与CD36协同介导膳食脂肪酸吸收的机制，为肠道脂代谢研究提供实验依据。
3. **标题**: *FATP4 regulates hepatic lipid droplet formation and protects against steatosis in obesity*
**作者**: K. Goto et al.
**摘要**: 使用FATP4抗体检测肥胖模型小鼠肝脏组织，发现FATP4通过调控脂滴形成抑制脂肪肝发生，提示其潜在代谢保护功能。
4. **标题**: *Antibody-based localization of FATP4 in the murine placenta reveals a role in maternal-fetal lipid transfer*
**作者**: T. Grevengoed et al.
**摘要**: 通过免疫荧光和FATP4抗体定位，发现其在胎盘滋养层细胞高表达，可能参与母胎间脂肪酸转运，为胎儿发育研究提供新视角。
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**注意**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台以关键词“SLC27A4/FATP4 antibody”或“FATP4 immunohistochemistry”检索，并筛选涉及抗体应用的研究(如蛋白定位、表达分析等)。
The solute carrier family 27 member 4 (SLC27A4), also known as fatty acid transport protein 4 (FATP4), is a transmembrane protein critical for cellular uptake and metabolism of long-chain fatty acids. It is highly expressed in tissues with active lipid metabolism, including the small intestine, skin, and adipose tissue. FATP4 functions both as a fatty acid transporter and an acyl-CoA synthetase, facilitating fatty acid internalization and activation for metabolic pathways like triglyceride synthesis or β-oxidation. Research links FATP4 to insulin resistance, obesity, and lipid-related disorders, with mutations associated with ichthyosis prematurity syndrome (IPS) and disrupted epidermal lipid homeostasis.
Antibodies targeting SLC27A4/FATP4 are essential tools for studying its expression, localization, and functional roles. They are widely used in Western blotting, immunohistochemistry, and immunofluorescence to investigate tissue-specific distribution or alterations under metabolic conditions. Such antibodies also aid in exploring FATP4’s involvement in diseases; for example, reduced FATP4 levels correlate with impaired lipid absorption in intestinal models, while skin-specific knockout studies highlight its role in maintaining epidermal barrier integrity. Additionally, therapeutic research leverages these antibodies to validate targeting strategies for metabolic syndromes or genetic lipid disorders. Validation of antibody specificity remains crucial due to structural similarities among FATPs.
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