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Rabbit Monoclonal PFDN5 Antibody

  • 中文名: PFDN5抗体
  • 别    名: EIG 1; Eig1; MM1; PFD5; PFDN5; Prefoldin 5; ;PFDN5
货号: IPDX17854
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20-1/50 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesEIG 1; Eig1; MM1; PFD5; PFDN5; Prefoldin 5; ;PFDN5
WB Predicted band size17 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human PFDN5
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是几篇关于PFDN5抗体的模拟参考文献示例(请注意,以下内容为根据领域知识生成的示例,实际文献需通过学术数据库查询):

1. **文献名称**:*The role of PFDN5 in cancer progression and its potential as a biomarker*

**作者**:Chen L, et al.

**摘要**:研究通过PFDN5抗体检测发现,PFDN5在肺癌组织中高表达,并与患者预后不良相关,提示其可能作为癌症治疗的潜在靶点。

2. **文献名称**:*PFDN5 antibody-based detection of protein aggregation in neurodegenerative models*

**作者**:Smith JR, et al.

**摘要**:利用PFDN5抗体探究Prefoldin复合体在神经退行性疾病中的作用,发现PFDN5与α-synuclein聚集相关,可能参与阿尔茨海默病的病理过程。

3. **文献名称**:*Characterization of PFDN5 interaction networks using co-immunoprecipitation*

**作者**:Wang Y, et al.

**摘要**:通过PFDN5抗体进行免疫共沉淀实验,揭示了PFDN5与其他分子伴侣蛋白的相互作用,为理解其参与蛋白质折叠的分子机制提供依据。

4. **文献名称**:*PFDN5 expression dynamics under cellular stress conditions*

**作者**:Kim H, et al.

**摘要**:采用PFDN5抗体进行免疫荧光染色,发现热休克条件下PFDN5易位至细胞核,可能协助应激状态下的蛋白质稳态调节。

**提示**:以上为模拟示例,实际文献建议通过PubMed、Google Scholar或Web of Science检索关键词“PFDN5 antibody”“PFDN5 function”获取。真实研究可能涉及抗体应用(如Western Blot、IHC)、疾病机制或结构生物学方向。

背景信息

The PFDN5 antibody targets the protein Prefoldin Subunit 5 (PFDN5), a component of the prefoldin complex involved in chaperone-assisted protein folding. Prefoldin, a hexameric molecular chaperone, stabilizes nascent polypeptides and facilitates their transfer to the cytosolic chaperonin TRiC/CCT for proper folding. PFDN5. also known as MM-1 or C-MYC-binding protein, plays roles beyond its chaperone function, including regulating transcription factors like c-MYC. Studies link PFDN5 to cancer biology, where it acts as a tumor suppressor by inhibiting c-MYC-mediated cell proliferation and promoting proteasomal degradation of oncoproteins. Dysregulation of PFDN5 expression is observed in malignancies such as glioblastoma and leukemia. Additionally, PFDN5 antibodies are essential tools for detecting protein expression levels in tissues or cell lines via techniques like Western blot, immunohistochemistry, and immunofluorescence. Research using these antibodies has elucidated PFDN5's involvement in cellular stress responses, neurodegenerative diseases, and its potential as a diagnostic or prognostic biomarker. Commercial PFDN5 antibodies are typically raised in rabbits or mice, with validation emphasizing specificity through knockout controls or siRNA knockdowns. Ongoing studies explore its therapeutic relevance in targeting oncogenic pathways.

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