Rabbit Monoclonal PFDN5 Antibody

The PFDN5 antibody targets the protein Prefoldin Subunit 5 (PFDN5), a component of the prefoldin complex involved in chaperone-assisted protein folding. Prefoldin, a hexameric molecular chaperone, stabilizes nascent polypeptides and facilitates their transfer to the cytosolic chaperonin TRiC/CCT for proper folding. PFDN5. also known as MM-1 or C-MYC-binding protein, plays roles beyond its chaperone function, including regulating transcription factors like c-MYC. Studies link PFDN5 to cancer biology, where it acts as a tumor suppressor by inhibiting c-MYC-mediated cell proliferation and promoting proteasomal degradation of oncoproteins. Dysregulation of PFDN5 expression is observed in malignancies such as glioblastoma and leukemia. Additionally, PFDN5 antibodies are essential tools for detecting protein expression levels in tissues or cell lines via techniques like Western blot, immunohistochemistry, and immunofluorescence. Research using these antibodies has elucidated PFDN5's involvement in cellular stress responses, neurodegenerative diseases, and its potential as a diagnostic or prognostic biomarker. Commercial PFDN5 antibodies are typically raised in rabbits or mice, with validation emphasizing specificity through knockout controls or siRNA knockdowns. Ongoing studies explore its therapeutic relevance in targeting oncogenic pathways.