| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ERGIC5; F5F8D; FMFD1; Gp58; Lman1; MCFD1; MR60;;LMAN1 |
| WB Predicted band size | 58 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human LMAN1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于LMAN1抗体的参考文献示例(文献信息为模拟内容，仅供参考)：
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1. **文献名称**: *LMAN1 is a molecular chaperone for the secretion of coagulation factors*
**作者**: Zhang B, et al.
**摘要**: 本研究利用LMAN1特异性抗体，通过免疫共沉淀和免疫荧光技术，揭示了LMAN1作为内质网-高尔基体运输分子伴侣的功能，并证明其缺失会导致凝血因子V和VIII的分泌缺陷。
2. **文献名称**: *Mutation in LMAN1 disrupts ER exit and causes combined deficiency of coagulation factors*
**作者**: Bussaglia E, et al.
**摘要**: 通过LMAN1抗体对患者细胞进行Western blot和免疫组化分析，发现LMAN1基因突变导致蛋白错误定位，进而引发凝血因子分泌异常，阐明了遗传性凝血障碍的分子机制。
3. **文献名称**: *LMAN1 antibody-based detection of protein trafficking defects in cancer cells*
**作者**: Nguyen T, et al.
**摘要**: 研究利用抗LMAN1单克隆抗体，在多种癌细胞系中发现LMAN1表达下调与肿瘤转移相关蛋白的异常糖基化有关，提示其可能作为癌症预后标志物。
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注：以上文献为示例，实际文献需通过PubMed或Google Scholar检索关键词“LMAN1 antibody”或结合具体研究领域筛选。建议补充实际数据库检索结果。
LMAN1 (Lectin, Mannose-Binding 1), also known as ERGIC-53 or F5F8D, is a transmembrane glycoprotein that functions as a cargo receptor in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). It plays a critical role in the selective transport of glycoproteins, including coagulation factors V and VIII, by recognizing mannose-rich oligosaccharides. Mutations in the *LMAN1* gene are linked to combined deficiency of factors V and VIII (F5F8D), a rare autosomal recessive bleeding disorder characterized by reduced levels of these clotting factors.
LMAN1 antibodies are essential tools for studying intracellular protein trafficking, ER-Golgi dynamics, and disease mechanisms. In research, they are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to visualize LMAN1 expression, localization, and interactions. These antibodies also aid in investigating secretory pathway defects, ER-associated degradation (ERAD), and viral infections (e.g., hepatitis C virus entry). Commercial LMAN1 antibodies are typically raised against specific epitopes, validated for species reactivity (human, mouse, rat), and available in monoclonal or polyclonal formats. Their applications extend to exploring cancer biology, as altered LMAN1 expression has been observed in certain tumors, suggesting potential roles in tumor progression or suppression.
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