首页 / 产品 / 抗体 / 一抗

Rabbit Monoclonal 2-Oct Antibody

  • 中文名: 2-Oct抗体
  • 别    名: NF A2; Oct 2; Oct-2; OTF-2; OTF2; POU2F2; ;45567
货号: IPDX17850
Price: ¥1280
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/20-1/50 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesNF A2; Oct 2; Oct-2; OTF-2; OTF2; POU2F2; ;45567
WB Predicted band sizeCalculated MW: 51 kDa ; Observed MW: 58 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Oct 2
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

+ +

参考文献

以下是关于2-Oct(或Oct-2)抗体的虚构参考文献示例(仅供参考,非真实文献):

---

1. **文献名称**: *Oct-2 regulates B cell-specific immunoglobulin gene expression*

**作者**: Smith, J., et al.

**摘要**: 研究探讨了转录因子Oct-2在B淋巴细胞中对免疫球蛋白基因的调控作用,利用Oct-2抗体进行染色质免疫沉淀(ChIP)实验,证实其直接结合于IgH基因增强子区域。

2. **文献名称**: *Role of Oct-2 in autoimmune disorders: Insights from antibody-mediated knockdown models*

**作者**: Lee, H., & Martinez, R.

**摘要**: 通过Oct-2抗体阻断实验,发现Oct-2在多发性硬化症患者B细胞中异常高表达,提示其可能通过调控炎症因子参与自身免疫反应。

3. **文献名称**: *Structural characterization of Oct-2 DNA-binding domain using monoclonal antibodies*

**作者**: Gupta, S., et al.

**摘要**: 报道了一种高特异性Oct-2单克隆抗体的开发,通过X射线晶体学揭示了Oct-2蛋白与DNA结合的分子机制,为靶向药物设计提供依据。

4. **文献名称**: *Oct-2 as a biomarker in lymphoma: Immunohistochemical analysis*

**作者**: Tanaka, K., et al.

**摘要**: 利用Oct-2抗体对淋巴瘤组织样本进行免疫组化分析,发现Oct-2高表达与B细胞淋巴瘤的恶性程度及预后不良显著相关。

---

注:以上文献为示例性质,实际研究中请通过学术数据库(如PubMed)查询真实发表的论文。

背景信息

The 2-Oct antibody, often associated with the transcription factor Oct-2. is a protein of interest in molecular biology and immunology. Oct-2 belongs to the POU (Pit-Oct-Unc) domain family of transcription factors, which regulate gene expression by binding to specific DNA sequences. Oct-2 is predominantly expressed in B lymphocytes and neuronal cells, where it plays a critical role in B-cell development, differentiation, and immunoglobulin gene regulation. Its interaction with coactivators like BOB.1 (OBF-1) enhances transcriptional activation, particularly at immunoglobulin promoters, making it essential for adaptive immunity.

In research, the 2-Oct antibody is widely used to detect Oct-2 protein levels in experimental models, aiding studies on B-cell malignancies, autoimmune disorders, and neurological diseases. Aberrant Oct-2 expression has been linked to conditions such as systemic lupus erythematosus (SLE) and certain B-cell lymphomas. The antibody’s applications include Western blotting, immunohistochemistry, and flow cytometry, providing insights into cellular localization and expression dynamics. Additionally, Oct-2’s role in neuronal gene regulation has spurred investigations into neurodegenerative diseases. Despite its specificity, cross-reactivity with related POU proteins (e.g., Oct-1) requires careful validation. Overall, the 2-Oct antibody remains a vital tool for dissecting transcriptional mechanisms in immunity and neurobiology.

客户数据及评论

折叠内容

大包装询价

×