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Rabbit Monoclonal TMEM173 Antibody

  • 中文名: TMEM173抗体
  • 别    名: ERIS; hMITA; hSTING; MITA; MPYS; NET23; STING; Tmem173; STING1;Stimulator of interferon genes protein;;STING
货号: IPDX17833
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesERIS; hMITA; hSTING; MITA; MPYS; NET23; STING; Tmem173; STING1;Stimulator of interferon genes protein;;STING
WB Predicted band sizeCalculated MW: 42 kDa ; Observed MW: 37 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human STING
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是3篇与TMEM173(STING)抗体相关的研究文献及其摘要概括:

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1. **文献名称**:*STING is a direct innate immune sensor of cyclic di-GMP*

**作者**:Burdette DL et al.

**摘要**:该研究首次证实STING(由TMEM173编码)作为先天免疫的关键传感器,直接识别细菌第二信使c-di-GMP。作者通过免疫沉淀和Western blot技术,使用特异性STING抗体验证了其与c-di-GMP的相互作用,并揭示了其在激活I型干扰素通路中的作用。

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2. **文献名称**:*Antitumor immune responses via STING activation in cancer immunotherapy*

**作者**:Woo SR et al.

**摘要**:研究探讨了STING激动剂在肿瘤微环境中激活抗肿瘤免疫的机制。通过免疫组化(IHC)和流式细胞术结合TMEM173抗体,作者发现STING激活可增强树突状细胞抗原呈递,促进CD8+ T细胞浸润,显著抑制小鼠肿瘤生长。

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3. **文献名称**:*Activated STING in a vascular and pulmonary syndrome*

**作者**:Liu Y et al.

**摘要**:本文报道了一种由TMEM173基因功能获得性突变引起的自身炎症性疾病。研究利用STING特异性抗体进行免疫荧光染色,发现突变导致STING蛋白在内皮细胞中异常聚集,引发慢性的I型干扰素反应和血管炎症。

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4. **文献名称**:*STING-dependent cytosolic DNA sensing pathways in autoimmune disease*

**作者**:Gall A et al.

**摘要**:该研究分析了STING通路在系统性红斑狼疮(SLE)中的作用。通过Western blot和免疫共沉淀(Co-IP)技术,作者使用TMEM173抗体证明患者外周血细胞中STING蛋白表达上调,且与干扰素特征基因的表达呈正相关。

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这些文献涵盖了STING抗体的典型应用场景(如Western blot、免疫组化、免疫荧光),并关联了其在先天免疫、肿瘤治疗和自身免疫疾病中的机制研究。

背景信息

The TMEM173 gene encodes the stimulator of interferon genes (STING) protein, a critical component of the innate immune system. STING acts as a cytosolic sensor for cyclic dinucleotides, such as cGAMP, produced by the cGAS enzyme in response to cytosolic DNA. This pathway triggers the production of type I interferons (IFNs) and pro-inflammatory cytokines, linking cellular stress or pathogen detection to immune activation. TMEM173 antibodies are essential tools for studying STING's expression, localization, and function in various physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and flow cytometry to investigate STING's role in autoimmune diseases (e.g., lupus), cancer immunotherapy, and viral infections. Research has highlighted STING's dual role: its activation can promote antitumor immunity by enhancing dendritic cell/T-cell responses, while chronic activation may drive autoimmune disorders. Antibodies targeting specific STING epitopes or post-translational modifications (e.g., phosphorylation) help dissect its regulatory mechanisms, including interactions with proteins like TBK1 or IRF3. Additionally, TMEM173 antibodies aid in evaluating STING agonists/inhibitors as therapeutic candidates, particularly in cancer and inflammatory diseases. Recent studies also explore STING's involvement in metabolic syndromes and neurodegenerative conditions, expanding its immunological significance.

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