Rabbit Monoclonal TMEM173 Antibody

The TMEM173 gene encodes the stimulator of interferon genes (STING) protein, a critical component of the innate immune system. STING acts as a cytosolic sensor for cyclic dinucleotides, such as cGAMP, produced by the cGAS enzyme in response to cytosolic DNA. This pathway triggers the production of type I interferons (IFNs) and pro-inflammatory cytokines, linking cellular stress or pathogen detection to immune activation. TMEM173 antibodies are essential tools for studying STING's expression, localization, and function in various physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and flow cytometry to investigate STING's role in autoimmune diseases (e.g., lupus), cancer immunotherapy, and viral infections. Research has highlighted STING's dual role: its activation can promote antitumor immunity by enhancing dendritic cell/T-cell responses, while chronic activation may drive autoimmune disorders. Antibodies targeting specific STING epitopes or post-translational modifications (e.g., phosphorylation) help dissect its regulatory mechanisms, including interactions with proteins like TBK1 or IRF3. Additionally, TMEM173 antibodies aid in evaluating STING agonists/inhibitors as therapeutic candidates, particularly in cancer and inflammatory diseases. Recent studies also explore STING's involvement in metabolic syndromes and neurodegenerative conditions, expanding its immunological significance.